Abstract:We have shown that the cellular mechanisms of the mammary gland can be used to produce a phosphorylated form of a normally unphosphorylated milk protein. This was achieved by the insertion of a β-casein DNA sequence coding for a group of mammary gland casein kinase recognition sites into ovine β-lactoglobulin. Transgenic mice carrying this modified gene were generated and lactating females were shown to produce a novel β-lactoglobulin in their milk. The infrared spectrum, reactivity to antiphosphoserine antibo… Show more
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