Insertion–Deletion Events Are Depleted in Protein Regions with Predicted Secondary Structure
Yi Yang,
Matthew V Braga,
Matthew D Dean
Abstract:A fundamental goal in evolutionary biology and population genetics is to understand how selection shapes the fate of new mutations. Here we test the null hypothesis that insertion-deletion events (indels) in protein coding regions occur randomly with respect to secondary structures. We identified indels across 11,444 sequence alignments in mouse, rat, human, chimp, and dog genomes, then quantified their overlap with four different types of secondary structure – alpha helices, beta strands, protein bends, and p… Show more
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