Insensible Water Loss From the Medtronic Minimax Oxygenator: An in Vitro Study

Alexander, Plato; Lawson, D. Scott; Cornell, Jack; Cheifetz, Ira M.

doi:10.1097/00003246-200412001-00180

Cited by 4 publications

(12 citation statements)

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“…The daily loss we recorded, using the Hilite ® 2400LT PMP membrane, was 72.4 ml/day per L/min/gas flow. Camacho et al 4 recorded 72ml/day per L/min/gas flow, utilising a silicone membrane, Alexander et al 5 reported 83 ml/day with a microporous, hollow-fibre membrane, and Lawson and Holt 6 measured 48 ml/day with the PMP membrane within the Quadrox D.…”

Section: Discussionmentioning

confidence: 99%

“…Camacho et al, 4 using a silicone membrane oxygenator, reported a 72-ml water loss over a 24-hour period, per litre/minute (L/min) of gas flow. Alexander et al 5 studied a microporous, hollow-fibre, membrane oxygenator and reported an 83-ml water loss over a 24 hour period, per L/min gas flow. Of particular interest, due to the membrane material under investigation, was a study by Lawson and Holt.…”

Section: Introductionmentioning

confidence: 99%

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Insensible water loss from the Hilite 2400LT oxygenator: an in vitro study

Gill¹,

O'Shaughnessy²

2012

Perfusion

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insensible water loss from the Hilite 2400LT oxygenator: an in vitro study

Gill¹,

O'Shaughnessy²

2012

Perfusion

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“…12,13 Furthermore, water loss is inversely proportional to the membrane thickness, and it is influenced by the micro-structure of the membrane material as well as the size of the pores, if any, in the membrane. 32 Moreover, the method of micro-pore manufacturing could also influence the amount of water leakage. 33…”

Section: Oxygenator Performancementioning

confidence: 99%

“…Meanwhile, the use of transfused whole animal blood would have carried intrinsic limitations, based on the red blood cells relatively short half-life in the in vitro setting and physical size differences in between species. 32 Initial studies have mainly used roller pumps, while more recent tests employed centrifugal pumps. Temperature was controlled with heat exchangers connected to the ECMO circuit or directly integrated to the MO.…”

Section: Oxygenator Performancementioning

confidence: 99%

Ex vivo models for research in extracorporeal membrane oxygenation: a systematic review of the literature

Malfertheiner

Broman

Vercaemst³

et al. 2020

Perfusion

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With ongoing progress of components of extracorporeal membrane oxygenation including improvements of oxygenators, pumps, and coating materials, extracorporeal membrane oxygenation became increasingly accepted in the clinical practice. A suitable testing in an adequate setup is essential for the development of new technical aspects. Relevant tests can be conducted in ex vivo models specifically designed to test certain aspects. Different setups have been used in the past for specific research questions. We conducted a systematic literature review of ex vivo models of extracorporeal membrane oxygenation components. MEDLINE and Embase were searched between January 1996 and October 2017. The inclusion criteria were ex vivo models including features of extracorporeal membrane oxygenation technology. The exclusion criteria were clinical studies, abstracts, studies in which the model of extracorporeal membrane oxygenation has been reported previously, and studies not reporting on extracorporeal membrane oxygenation components. A total of 50 studies reporting on different ex vivo extracorporeal membrane oxygenation models have been identified from the literature search. Models have been grouped according to the specific research question they were designed to test for. The groups are focused on oxygenator performance, pump performance, hemostasis, and pharmacokinetics. Pre-clinical testing including use of ex vivo models is an important step in the development and improvement of extracorporeal membrane oxygenation components and materials. Furthermore, ex vivo models offer valuable insights for clinicians to better understand the consequences of choice of components, setup, and management of an extracorporeal membrane oxygenation circuit in any given condition. There is a need to standardize the reporting of pre-clinical studies in this area and to develop best practice in their design.

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“…20,21 Despite the absence of regulatory agency approval and the frequent incidence of oxygenator gas exit water and plasma leakage, clinicians have demonstrated the safe extended use of microporous membrane oxygenators. 22 Oxygenator change-out must be practiced, planned for, and performed competently by ECMO specialists and perfusionist primers when micro porous membrane oxygenators are included in the ECLS circuit. 23 One manufacturer has developed a "diffusion" membrane that is not microporous (Quadrox D , Maquet Cardiopulmonary AG, Rastatt, Germany, http://www.maquet.com/cardiopulmonary) and is less subject to gas-phase plasma leakage and the creation of microbubbles if the gas path is pressurized or the blood path pressure is negative.…”

Section: Blood Oxygenatorsmentioning

confidence: 99%

Update on Safety Equipment for Extracorporeal Life Support (ECLS) Circuits

Riley

Scott

Schears

2009

Semin Cardiothorac Vasc Anesth

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Though much has been surveyed and written about the equipment aspects of extracorporeal life support (ECLS) in the past 10 years, there is value in reviewing the use and nonuse of multiple safety devices and techniques. Minimally equipped ECLS circuits for adult and pediatric bridge to decision during cardiac and respiratory failure are rapidly gaining popularity to maintain simplicity and portability. ECLS circuits employed for long-term therapy are outfitted differently and should include more safety devices. The purpose of this review is to compare and contrast the spectrum of minimally equipped ECLS circuits to circuits with maximum flexibility and safety device protection. Due to the lack of high-level, well-controlled scientific studies regarding ECLS equipment and safety devices, this study reviews the basis for how we use ECLS circuits and devices in our institution to provide safe patient support.

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Insensible Water Loss From the Medtronic Minimax Oxygenator: An in Vitro Study

Cited by 4 publications

References 0 publications

Insensible water loss from the Hilite 2400LT oxygenator: an in vitro study

Insensible water loss from the Hilite 2400LT oxygenator: an in vitro study

Ex vivo models for research in extracorporeal membrane oxygenation: a systematic review of the literature

Update on Safety Equipment for Extracorporeal Life Support (ECLS) Circuits

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