Insecticides in the tissues of four generations of rats fed different dietary fats containing a mixture of chlorinated hydrocarbon insecticides

Abstract

From weaning, four generations of male and female rats were fed diets containing different fats and a mixture of DDT, DDE, DDD, dieldrin, lindane, BHC, heptachlor epoxide, methoxychlor, and Perthane. DDT, DDD, DDE, and dieldrin

The effects of environmental hormones on reproduction

“…Evidence that the environment is contaminated with known endocrine disruptors Although many xenobiotics in the environment have weak hormonal activity as compared with endogenous steroids [1, 4, 82], their lipophilic nature and long halflives allow them to accumulate and persist in fatty tissues of the body, thus increasing their concentration and bioavailability [14,[105][106][107]. Many studies have been conducted to determine the concentration of environmental contaminants, especially organochlorine compounds, in the tissues of various species [108,109] including humans [110].…”

Chlorinated hydrocarbon insecticide residues in tissues of rats before and after reduction of body fat by dietary restriction

“…Experiments dealing with level and kind of protein or fat and with vitamin deficiencies have primarily focused on individual chlorinated hydrocarbon insecticides (Sauberlich and Baumann, 1947;Lee et al, 1964;Tinsley, 1966;Weatherholtz, et al, 1969; Stoewsand et al, 1970; Oshiba and Kawakita, 1972; Zabik and Schemmel, 1973;and Miranda and Webb, 1974). Adams et al (1974) studied the response of rats to a mixture of nine chlorinated hydrocarbon insecticides when source and treatment of dietary fat were the variables. They reported that the type of dietary fat in general exerted little influence on tissue content of DDT, DDE, and dieldrin.…”

“…Deposition, accumulation, and mobilization of individual chlorinated hydrocarbon insecticides have been examined extensively with the rat as an experimental model. However, information is limited on the effects of feeding two or more insecticides for an extended time (Adams et al, 1974). The use of a mixture of CHI provides a realistic approach for the study of the effects of diet on storage of CHI in the body.…”

“…An aliquot of the homogenate was weighed, dried, and ground with sodium sulfate. The resulting mixture was extracted for gas-chromatographic analysis of CHI and analyzed by Crobaugh Laboratories as described by Adams et al (1974).…”