Insecticide Resistance in Anopheles gambiae Giles

Elliott, Richard; Ramakrishna, V.

doi:10.1038/177532a0

Cited by 27 publications

(9 citation statements)

References 2 publications

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“…Dieldrin resistance was first described in An. gambiae in Nigeria [75]. It was shown to be inherited in a simple Mendelian fashion with evidence of two resistance alleles for the same locus, one dominant and the other codominant [76-78].…”

Section: Cyclodiene and Phenyl Pyrazole Resistancementioning

confidence: 99%

Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae

Brooke

Koekemoer

2010

Parasites Vectors

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Insecticide use in public health and agriculture presents a dramatic adaptive challenge to target and non-target insect populations. The rapid development of genetically modulated resistance to insecticides is postulated to develop in two distinct ways: By selection for single major effect genes or by selection for loose confederations in which several factors, not normally associated with each other, inadvertently combine their effects to produce resistance phenotypes. Insecticide resistance is a common occurrence and has been intensively studied in the major malaria vector Anopheles gambiae, providing a useful model for examining how insecticide resistance develops and what pleiotropic effects are likely to emerge as a consequence of resistance. As malaria vector control becomes increasingly reliant on successfully managing insecticide resistance, the characterisation of resistance mechanisms and their pleiotropic effects becomes increasingly important.

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Section: Cyclodiene and Phenyl Pyrazole Resistancementioning

confidence: 99%

Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae

Brooke

Koekemoer

2010

Parasites Vectors

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“…Such conditions can result from vector control through insecticide decay (on treated walls or nets) or bad spraying technique. Insecticide resistance was first reported in malaria vectors in the 1950s [11], and resistance to dichlorodiphenyltrichloroethane (DDT) and pyrethroids is now widespread [12]. Resistance is predicted to impair malaria control efforts but evidences from field studies remain limited and potentially conflicting [7].…”

Section: Introductionmentioning

confidence: 99%

Insecticide Resistance in Malaria Vectors: An Update at a Global Scale

Riveron¹,

Tchouakui²,

Mugenzi³

et al. 2018

Towards Malaria Elimination - A Leap Forward

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Malaria remains the deadliest vector-borne disease in the world. With nearly half of the world's population at risk, 216 million people suffered from malaria in 2016, with over 400,000 deaths, mainly in sub-Saharan Africa. Important global efforts have been made to eliminate malaria leading to significant reduction in malaria cases and mortality in Africa by 42% and 66%, respectively. Early diagnosis, improved drug therapies and better health infrastructure are key components, but this extraordinary success is mainly due the use of long-lasting insecticidal nets (LLINs) and indoor residual sprayings (IRS) of insecticide. Unfortunately, the emergence and spread of resistance in mosquito populations against insecticides is jeopardising the effectiveness of the most efficient malaria control interventions. To help establish suitable resistance management strategies, it is vital to better understand the distribution of resistance, its mechanisms and impact on effectiveness of control interventions and malaria transmission. In this chapter, we present the current status of insecticide resistance worldwide in main malaria vectors as well as its impact on malaria transmission, and discuss the molecular mechanisms and future perspectives.

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“…Resistance to dieldrin in An. gambiae appeared in Nigeria only 18 months after a pilot control program using this insecticide (Elliot, 1956). Based on the difference in responses to different dieldrin dosages, two alleles were postulated: one conferring dominance and the other semidominance (Davidson, 1956; Davidson & Hamon, 1962).…”

Section: Introductionmentioning

confidence: 99%

Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis

Awolola

Howell

et al. 2005

Insect Molecular Biology

129

104

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Substitutions of a conserved alanine residue in the Rdl locus coding for a gamma-aminobutyric acid (GABA) receptor subunit with serine or glycine confer resistance to dieldrin in various insect species. Here, we show that alanine to glycine substitution in the Rdl locus of the malaria vector, Anopheles gambiae, is genetically linked to resistance to dieldrin. An alanine to serine substitution developed independently in a dieldrin resistant strain of An. arabiensis. An allele-specific polymerase chain reaction (PCR) assay was able to differentiate dieldrin resistant and susceptible mosquitoes.

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Insecticide Resistance in Anopheles gambiae Giles

Cited by 27 publications

References 2 publications

Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae

Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae

Insecticide Resistance in Malaria Vectors: An Update at a Global Scale

Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis

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