Insecticide Resistance and Dominance Levels

Bourguet, Denis; Génissel, Anne; Raymond, M.

doi:10.1603/0022-0493-93.6.1588

Cited by 295 publications

(343 citation statements)

References 62 publications

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“…Initially, the high-dose/refuge concept was motivated by resistance to B. thuringiensis toxins in other species being recessive, and by high expression levels of B. thurin- giensis toxins in plants ensuring that heterozygotes could not survive on Bt crops (Alstad and Andow 1995, Gould 1998, Roush 1998. However, the survival of heterozygous individuals depends not only on the dominance level but also on the resistance ratio and the doses expressed by transgenic Bt crops (Bourguet et al 2000). Thus, even an incompletely dominant B. thuringiensis resistance (Huang et al 1999a) could give a recessive Þtness at B. thuringiensis concentrations expressed by transgenic Bt corn (Bourguet et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…However, the survival of heterozygous individuals depends not only on the dominance level but also on the resistance ratio and the doses expressed by transgenic Bt crops (Bourguet et al 2000). Thus, even an incompletely dominant B. thuringiensis resistance (Huang et al 1999a) could give a recessive Þtness at B. thuringiensis concentrations expressed by transgenic Bt corn (Bourguet et al 2000). Furthermore, heterozygote survival may be inßuenced by variability in Bt expression among tissues, by the amount of resources available to the developing larva, and by larval density on host plants all of which contribute to variation in toxin exposure over space and time.…”

Section: Discussionmentioning

confidence: 99%

“…Resistant strains have been selected from populations collected in Iowa, Kansas, (Huang et al 1997(Huang et al , 1999a, and southeastern Minnesota (Bolin et al 1999). The high-dose refuge strategy currently recommended for U.S. corn production (Ostlie et al 1997, International Life Sciences Institute 1998 requires that the increased Þtness conferred by Bt resistance alleles is recessive, i.e., heterozygous individuals either do not survive at doses of toxin produced by Bt corn or survive but with a Þtness close to zero (Bourguet et al 2000). Survival and Þtness of heterozygotes depends not only on the dominance of B. thuringiensis resistance but also on the resistance level conferred by resistance alleles (Bourguet et al 2000).…”

mentioning

confidence: 99%

“…The high-dose refuge strategy currently recommended for U.S. corn production (Ostlie et al 1997, International Life Sciences Institute 1998 requires that the increased Þtness conferred by Bt resistance alleles is recessive, i.e., heterozygous individuals either do not survive at doses of toxin produced by Bt corn or survive but with a Þtness close to zero (Bourguet et al 2000). Survival and Þtness of heterozygotes depends not only on the dominance of B. thuringiensis resistance but also on the resistance level conferred by resistance alleles (Bourguet et al 2000). Therefore, it is important to determine whether the relatively low resistance ratio reported by Huang et al (1997Huang et al ( , 1999a and Bolin et al (1999) is a general feature in O. nubilalis populations or whether higher B. thuringiensis resistance can be obtained in laboratory-selected populations.…”

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confidence: 99%

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Chronic Exposure of the European Corn Borer (Lepidoptera: Crambidae) to Cry1Ab <I>Bacillus thuringiensis</I> Toxin

Chaufaux¹,

Seguin²,

Swanson³

et al. 2001

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Chronic Exposure of the European Corn Borer (Lepidoptera: Crambidae) to Cry1Ab <I>Bacillus thuringiensis</I> Toxin

Chaufaux¹,

Seguin²,

Swanson³

et al. 2001

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“…There are likely several pest‐ Bt crop and pestsystemic insecticide systems that meet this more relaxed criterion, but as estimation of the relevant dominance of resistance is still uncommon (Bourguet et al. 2000), we cannot yet be sure.…”

Section: Discussionmentioning

confidence: 96%

Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution

et al. 2017

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The evolution of resistance against pesticides is an important problem of modern agriculture. The high‐dose/refuge strategy, which divides the landscape into treated and nontreated (refuge) patches, has proven effective at delaying resistance evolution. However, theoretical understanding is still incomplete, especially for combinations of limited dispersal and partially recessive resistance. We reformulate a two‐patch model based on the Comins model and derive a simple quadratic approximation to analyze the effects of limited dispersal, refuge size, and dominance for high efficacy treatments on the rate of evolution. When a small but substantial number of heterozygotes can survive in the treated patch, a larger refuge always reduces the rate of resistance evolution. However, when dominance is small enough, the evolutionary dynamics in the refuge population, which is indirectly driven by migrants from the treated patch, mainly describes the resistance evolution in the landscape. In this case, for small refuges, increasing the refuge size will increase the rate of resistance evolution. Our analysis distils major driving forces from the model, and can provide a framework for understanding directional selection in source‐sink environments.

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Rapid ultraperformance liquid chromatography–tandem mass spectrometry method for quantification of oxcarbazepine and its metabolite in human plasma

Bhatt

Shah

Shivprakash³

2010

Biomedical Chromatography

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A rapid and sensitive ultraperformance liquid chromatography tandem mass spectrometry assay was developed for the simultaneous analysis of oxcarbazepine and its main metabolite in human plasma. The assay involves a simple solid-phase extraction procedure of 0.3 mL of human plasma and analysis was performed on a triple-quadrupole tandem mass spectrometer in multiple reaction monitoring mode via electrospray ionization. Separation was achieved on an Acquity UPLC™ BEH C₁₈ column (50 × 2.1 mm, i.d., 1.7 µm) with isocratic elution at a flow-rate of 0.25 mL/min and imipramine was used as the internal standard. The standard calibration curve was linear over the range 9.580-5070.205 ng/mL for oxcarbazepine (OXC) and 19.444-10290.800 ng/mL for 10,11-dihydro-10-hydroxycarbamazepine (MHD), expressed by the linear correlation coefficient r², which was better than 0.995 for OXC and MHD. The intra- and inter-day precision and accuracy of the quality control samples were within 10.0%. The recoveries were 81.0, 89.6 and 66.6% for OXC, MHD and imipramine, respectively. The total run time was 1.5 min only for each sample, which makes it possible to analyze more than 350 samples per day.

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Insecticide Resistance and Dominance Levels

Cited by 295 publications

References 62 publications

Chronic Exposure of the European Corn Borer (Lepidoptera: Crambidae) to Cry1Ab <I>Bacillus thuringiensis</I> Toxin

Chronic Exposure of the European Corn Borer (Lepidoptera: Crambidae) to Cry1Ab <I>Bacillus thuringiensis</I> Toxin

Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution

Rapid ultraperformance liquid chromatography–tandem mass spectrometry method for quantification of oxcarbazepine and its metabolite in human plasma

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