Insecticidal Properties and Mode of Action of 1-(2,6-Dihalogenbenzoyl)-3-phenylureas

Post, L. C.; Mulder, R.

doi:10.1021/bk-1974-0002.ch011

Cited by 12 publications

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“…1 Introduction Dimilin (PH 6040) is a moulting inhibitor of many insects which belongs to a new class of chemicals of the group 2,6-dihalogenated benzoyl-aryl urea (MULDER and GIJSWIJT 1973;ZABEL and OSTIJIC 1973;POST and MULDER 1974;MILLER 1974;SALAMA et al 1976). This compound (1-[4chlorophenyl-]3-[2,6-difluorobenzoyl]-urea) interferes with the deposition and biosynthesis of chitin, inhibits ecdysis and finally leads to the death of insect larvae.…”

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confidence: 99%

Effect of the moulting inhibitor Dimilin on the cotton leafworm Spodoptera littoralis Boisd. in Egypt

Salama

El-Din

1977

Zeitschrift für Angewandte Entomologie

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The urea analogue compound Dimilin (PH 6040) proved to be an effective ovicide against the eggs of Spodoptera littoralis. A lethal effect of 100 % was induced in the eggs at a concentration of 5 ppm. Also different larval instars were affected by concentrations of 30–50 ppm incorporated in their diet, where they died few days after feeding and during ecdysis. At sublethal doses, the compound induced developmental retardation and few deformities and in this view, it resembled juvenile hormone analogues. It seems that Dimilin has a specific mode of action which interferes with the deposition of chitin. The newly formed cuticle becomes less rigid and therefore it cannot withstand the internal pressure during ecdysis or give sufficient support to the muscles involved in ecdysis and thus resulting in an inability to cast the exuviae and finally in death. The fact that Dimilin induces no harmful effect on the parasites and predators in nature, in addition to its safety to warm blooded animals encourages its use on a wide scale quite safely and efficiently. Zusammenfassung Wirkungen des Häutungshemmers Dimilin auf die Baumwolleule, Spodoptera littoralis Boisd. in Ägypten Das Harnstoff‐Derivat Dimilin (PH 6040) erwies sich als wirksames Ovizid bei S. littoralis. Bei einer Konzentration von 5 ppm wurde 100 %ige Abtötung der Eier erreicht. Auch die Larvenstadien starben nach Aufnahme von mit Dimilin (30–50 ppm) versetzter Nahrung während der Häutung ab. Subletale Dosen verursachten Entwicklungsverzögerungen sowie Deformationen, womit sie an die Wirkungen von Juvenilanalogen erinnern. Es scheint, daß Dimilin eine spezifische Wirkungsweise besitzt, die in die chitinische Ablagerung eingreift. Die neu gebildete Cuticula wird weniger hart und kann daher weder dem während der Häutung vorhandenen inneren Druck standhalten noch den an der Häutung beteiligten Muskeln Halt geben. Daraus resultiert eine Unfähigkeit zum Abwerfen der Haut und schließlich der Tod. Dadurch, daß Dimilin die parasitischen und räuberischen Insekten schont, und ungiftig für Warmblüter ist, erhält es große Bedeutung für die künftige umweltschonende Schädlingsbekämpfung.

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confidence: 99%

Effect of the moulting inhibitor Dimilin on the cotton leafworm Spodoptera littoralis Boisd. in Egypt

Salama

El-Din

1977

Zeitschrift für Angewandte Entomologie

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“…Diflubenzuron is essentially a larvicide and an ovicide affecting the chitin deposition in the insect cuticle (Post & Mulder, 1974). Mortality is due to rupture of the new cuticle, or to starvation as the insect cannot cast its exuviae during ecdysis (Mulder & Gijswijt, 1973).…”

Section: Discussionmentioning

confidence: 99%

EFFECT OF DIFLUBENZURON ON THE PRODUCTIVITY OF THE KHAPRA BEETLE TROGODERMA GRANARIUM

Rajendran

Shivaramaiah

1983

Entomologia Exp Applicata

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The productivity of adults of Trogoderma granarium Everts that had been exposed as 3‐ day‐old larvae to 0.8, 1.6 and 12.8 mg a.i. (diflubenzuron)/kg diet was adversely affected. When 7‐day‐old larvae were exposed, the productivity was reduced only at the highest concentration. Diflubenzuron had little influence on the productivity of the survivors exposed as 14‐day‐old larvae. The highest dose of 12.8 mg a.i./kg diet caused 94, 80 and 76% mortality, respectively, in 3‐. 7‐ and 14‐day‐old larval treatments. Adult eclosion was not affected. RÉSUMÉ Effet du Difiubenzuron sur la productivité deTrogoderma granarium Des larves de Trogoderma granarium Everts, ǎgées de 3, 7 et 14 jours, ont été exposées au diflubenzuron diététique (de 0,05 à 12,8 mg/kg du régime) jusqu'à la nymphose. La productivité (descendants produits par chaque femelle) des survivantes, qui ont été exposées, à l'ǎge de 3 jours, à 0,8, 1,6 et 12,8 mg de diflubenzuron/kg de régime, était affectée. Quand des larves ǎgées de 7 jours étaient élevées sur ces régimes, la productivité n'était diminuée qu'à partir de 12,8 mg de diflubenzuron/kg de régime. La productivité des survivants n'était guère affectée quand les larves ǎgées de 14 jours étaient traitées. La dose maximale de 12,8 mg de diflubenzuron/kg de régime a produit une mortalité de 94,80% parmi les larves de 3 et 7 jours, et 76% de mortalité parmi les larves ǎgées de 14 jours. L'éclosion des adultes n'a pas été affectée.

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“…Although its precise site of action is not known, diflubenzuron has been shown to interfere with the biosynthesis of chitin in insect larvae (Post and Vincent, 1973). Previous reports have shown that both in vivo (Post and Mulder, 1974) and in vitro (Sowa and Marks, 1975;Marks and Sowa, 1976) diflubenzuron inhibits the incorporation of isotopically labeled chitin precursors into chitin. Diflubenzuron has the potential for controlling a large number of insects because of its unique mode of action.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Diflubenzuron on Several Weight Characteristics in Growing Male Broiler and Layer Chickens

Kubena

1981

Poultry Science

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Diflubenzuron (Dimilin, TH-6040; N-[[(4-chlorophenyl)-amino] carbonyl]-2,6-difluorobenzamide) was fed to male broiler and layer chickens at levels of 0, 2.5, 25, and 250 ppm from 1 day to 98 days of age. Characteristics measured were body weights, grams of feed per gram of body weight, testes weights, liver weights, comb weights, and feet weights. There were no consistent significant differences among the control, 2.5, 25, or 250 ppm groups in any of the characteristics measured. There was a trend for higher body weights in the chickens fed diets containing diflubenzuron.

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Insecticidal Properties and Mode of Action of 1-(2,6-Dihalogenbenzoyl)-3-phenylureas

Cited by 12 publications

References 0 publications

Effect of the moulting inhibitor Dimilin on the cotton leafworm Spodoptera littoralis Boisd. in Egypt

Effect of the moulting inhibitor Dimilin on the cotton leafworm Spodoptera littoralis Boisd. in Egypt

EFFECT OF DIFLUBENZURON ON THE PRODUCTIVITY OF THE KHAPRA BEETLE TROGODERMA GRANARIUM

The Influence of Diflubenzuron on Several Weight Characteristics in Growing Male Broiler and Layer Chickens

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