Insecticidal piperidine alkaloid from Microcos paniculata stem bark

Screening of plants found in the State of Amazonas, Brazil for activity against Aedes aegypti larvae

“…larvae from different parts of the world, such as, North America (Bergeron et al, 1996), Argentina, Bolivia, Brasil and Peru (Chantraine et al, 1998;Ciccia et al, 2000;Macedo et al, 1997), Trinidade and Tobago (Chariandy et al, 1999), Mali (Diallo et al, 2001), Negev Desert (Sathiyamoorthy et al, 1997) and Africa (Marston et al, 1993), among others, have been published and have revealed numerous examples of active plant extracts representing diverse taxonomic groups. More systematic and directed studies have revealed a number of very active plant extracts, essential oils, and isolated larvicidal phytochemicals (Bandara et al, 2000;Bernard et al, 1995;Hostettmann & Potterat, 1997;Latha & Ammini, 2000;Lee, 2000;Oberlies et al, 1998;Park et al, 2002;Pushpalatha & Muthukrishnan, 1999;Rahuman et al, 2000;Sharma et al, 1998;Thorsell et al, 1998). In the present study, we have screened polar extracts of mostly native plants from the Brazilian Amazon for activity against larvae of the hemorrhagic dengue fever vector, Aedes aegypti (Diptera: Culicidae), at a single test concentration of 500 µg / mL.…”

A novel Tetracyclic Sesquiterpene from the Genus <em>Hortonia</em>

“…The first fraction, which was inactive in the mosquito larvicidal assay, obtained from the MPLC fractionation of CH 2 Cl 2 extract of leaves of H. angustifolia was subjected to flash chromatography with CH 2 Cl 2 -hexane (1:1) as the eluent to yield the tetracyclic sesquiterpene (figure 1) (yield 2.3% with respect to leaf extract) as a colourless oil. Compound 1 was subjected to the mosquitolarvicidal assay using the 2 nd instar larvae of Aedes aegypti (Bandara et al, 2000) and antifungal assay with the fungus Cladosporium cladosporioides using the TLC bioassay technique (Klarman and Sanford, 1968).…”

A review of studies on bioactive compounds isolated from Sri Lankan flora

“…The MC 50 and LC 50 of the compound at 24, 48 and 72 h has indicated that a very few of the moribund larvae survived, most dying after about 72 h after treatment (Bandara et al, 2000).…”