Insecticidal Exposure may be the cause of Progression of Immune Disorders and Inflammatory Diseases Through Dys-Regulation of Cytokines

Ahmad, Latif; Dogar, M. Zahoor-ul-Hassan

doi:10.21276/iabcr.2016.2.3.4

Cited by 2 publications

(2 citation statements)

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“…There have been documented links of pesticide exposure with various inflammatory responses. According to Ahmad and Dogar, pesticides frequently produce reactive oxygen species which cause cellular and tissue damage [10]. As a consequence, the Nuclear factor-kappa B (NF-kB), a transcription factor essential for inflammatory responses, gets activated and produces a large amount of proinflammatory cytokines, especially IL-6, which then stimulate the liv-er to up-regulate the production of a large amount of acute phase proteins, CRP.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence from population studies has revealed an association between occupational exposure to pesticides and cardiovascular disease incidence [7][8][9]. Proinflammatory cytokine secretion [10,11], oxidative stress [12,13] and derangement of cardiac ion channels [14,15] might be possible links between OP pesticide exposure and the development of CVDs.…”

Section: Introductionmentioning

confidence: 99%

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Serum High-sensitivity C-reactive Protein Level and Corrected QT Interval in Agricultural Workers in Myanmar Exposed to Chronic Occupational Organophosphate Pesticides

Thandar

Naing

Sein

2021

J UOEH

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Although acute organophosphate (OP) pesticide poisoning is associated with the risk cardiovascular diseases (CVD), the association between chronic occupational OP pesticide exposure and CVD risk is limited. We investigated serum high-sensitivity C-reactive protein (hs-CRP) levels and QTc intervals in 45 agricultural workers who were chronically exposed to OP pesticides and 45 non-exposed subjects. Serum hs-CRP level was determined by enzyme-linked immunosorbent assay (ELISA) and a level >1.0 mg/l was regarded as CVD risk. The QT interval was measured by routine 12-lead Electrocardiogram (ECG) with Lead II rhythm, and QTc was calculated. The median value of the serum hs-CRP level [1.20 (0.67-2.38) vs 0.74 (0.41-1.17) mg/l, P <0.05] and the mean QTc interval (422.71 ± 23.73 vs 396.27 ± 18.48 ms, P <0.0001) was significantly higher in the OP pesticide exposed subjects. Pesticide exposure was significantly associated with CVD risk (Chi-Square χ 2 = 6.480, P = 0.011) and QTc interval prolongation (χ 2 = 13.846, P <0.001). A higher risk of CVD (odds ratio = 3.030; 95% confidence interval = 1.276 -7.197) was observed in the OP pesticide exposed subjects. This study suggested that OP pesticide exposure should be considered as one of the significant risk factors for CVDs.

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Section: Discussionmentioning

confidence: 99%