Insecticidal and Repellent Activity of Siparuna guianensis Aubl. (Negramina) against Aedes aegypti and Culex quinquefasciatus

Aguiar, Raimundo Wagner Souza; Santos, Suetônio Fernandes dos; Morgado, Fabrício da Silva; Ascencio, Sergio Donizeti; Lopes, Magnólia de Mendonça; Viana, Kelvinson Fernandes; Didonet, Julcemar; Ribeiro, Bergmann Morais

doi:10.1371/journal.pone.0116765

Cited by 59 publications

(55 citation statements)

References 28 publications

(34 reference statements)

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“…Phytochemical studies have shown that essential oils can be obtained from dried and fresh leaves, as well as from stems and fruits; however, the leaves comprise the part of the plant with the highest yield in extraction according to the literature on S. guianensis (Aguiar et al, 2015); therefore, the leaves were chosen as the object of this study. The extraction of the essential oil from the plant was performed by the hydrodistillation process using the Clevenger apparatus.…”

Section: Resultsmentioning

confidence: 99%

“…They were then crushed and submitted to hydrodistillation extraction in a Clevenger apparatus (Aguiar et al, 2015). A mixture of 300 g of fresh crushed leaves and 1000 mL of distilled water was heated in a 2-L flask, and the vapors generated were directed to a condensation column coupled to a cooling system.…”

Section: Obtaining the Essential Oilmentioning

confidence: 99%

“…The temperature of the column was programmed to range from 65 to 210°C using a heating ramp at a rate of 3°C/min. Mass spectra were obtained in the range of 40 to 650 amu, operating at 70 V, and the source was maintained at 200°C (Aguiar et al, 2015).…”

Section: Gas Chromatography and Mass Spectrophometry (Gc-ms)mentioning

confidence: 99%

“…It has also been reported to be used for fluctuation of consciousness between hypoactive and hyperactive states, neck pains, muscle strains, fears, vomiting, and seizures (Pagania et al, 2017). The essential oil of this plant has also been studied for the biological control of pests, wherein it has been recently used for the control of Aedes aegypti Linnaeus, 1762 (Diptera: Culicidae) and Culex quinquefasciatus Say, 1823 (Diptera: Culicidae) with interesting results (Aguiar et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…It has also been evaluated for its activity against the promastigotes of Leishmania amazonensis (Andrade et al, 2016) and as a repellent (Aguiar et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Influence of seasonality on the yield and composition of the essential oil of Siparuna guianensis Aublet

Ferreira¹,

Kuckelhaus²,

Tschoeke³

et al. 2017

Afr. J. Biotechnol.

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The plant Siparuna guianensis is used in traditional medicine and has been the target of studies on the development of new drugs for the control of pests and vector insects. The present study was aimed to evaluate the seasonal influence on the content and composition of the essential oil of S. guianensis. The experiment was conducted for 12 months evaluating the yield of the essential oil of leaves throughout the seasons (autumn, winter, spring and summer). The chemical composition of the essential oil was obtained by gas chromatography-mass spectrometry (GC-MS). The highest oil yield was in autumn and winter, comprising 0.33 and 0.29% (w/w), respectively. The major compound identified was β-myrcene (48.59-24.2%), followed by epicurzerenone (27.24-13.7%) being the most abundant; germacrene D showed lower values of 9.93% in autumn and 13.5-14.34% in the other seasons, besides curzerene that had no production in autumn. The ɣ-elemene component had a higher production of 7.29% in autumn. Compound 2-undecanone did not show significant seasonal changes, with percentages being between 7.26 and 5.43%. The monoterpenes and sesquiterpenes showed similar levels in autumn; however, in the other seasons (winter, spring, and summer), the sesquiterpenes presented higher concentration, reaching 68.54% in summer. The components identified in the essential oil of S. guianensis exhibit interesting biological activities, making this essential oil a promising compound for the development of new biodegradable drugs, repellents, and insecticides. The knowledge about the yield and seasonal composition is fundamental to optimize and maximize the obtainment of compounds of interest for the production of new drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Obtaining the Essential Oilmentioning

confidence: 99%

Section: Gas Chromatography and Mass Spectrophometry (Gc-ms)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…It has also been evaluated for its activity against the promastigotes of Leishmania amazonensis (Andrade et al, 2016) and as a repellent (Aguiar et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influence of seasonality on the yield and composition of the essential oil of Siparuna guianensis Aublet

Ferreira¹,

Kuckelhaus²,

Tschoeke³

et al. 2017

Afr. J. Biotechnol.

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show abstract

Essential Oil‐Based Biopesticides

Sharma

Gupta

et al. 2023

Essential Oils

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Identification of Bioactive Compounds against Aedes aegypti (Diptera: Culicidae) by Bioassays and in Silico Assays

Brito

Oliveira

Silva

et al. 2021

Chemistry & Biodiversity

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Most of the hematophagous insects act as disease vectors, including Aedes aegypti, responsible for transmitting some of the most critical arboviruses globally, such as Dengue. The use of repellents based on natural products is a promising alternative for personal protection compared to industrial chemical repellents. In this study, the repellent effect of essential oils extracted from Lippia thymoides, Lippia alba, Cymbopogon winterianus, and Eucalyptus globulus leaves was evaluated. Essential oils used showed repellent activity against Ae. aegypti in laboratory bioassays, obtaining protection rates above 70 % from 3.75 mg/mL and higher concentration for all analyzed oils. GC/MS identified 57 constituents, which were used in the ligand‐based pharmacophore model to expose compounds with requirements for repellents that modulate mosquitoes behavior through odorant‐binding protein 1 Ae. aegypti. Ligand‐based pharmacophore model approach results suggested that repellent activity from C. winterianus, L. alba, and L. thymoides essential oils’ metabolites is related to Citronelal (QFIT=26.77), Citronelol (QFIT=11.29), Citronelol acetate (QFIT=52.22) and Geranil acetate (QFIT=10.28) with synergistic or individual activity. E. globulus essential oil's repellent activity is associated with Ledol (0.94 %; QFIT=41.95). Molecular docking was applied to understand the binding mode and affinity of the essential oils’ data set at the protein binding site. According to molecular docking, Citronelol (ChemPLP=60.98) and geranyl acetate (ChemPLP=60.55) were the best‐classified compounds compared to the others and they can be explored to develop new repellents.

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Insecticidal and Repellent Activity of Siparuna guianensis Aubl. (Negramina) against Aedes aegypti and Culex quinquefasciatus

Cited by 59 publications

References 28 publications

Influence of seasonality on the yield and composition of the essential oil of Siparuna guianensis Aublet

Influence of seasonality on the yield and composition of the essential oil of Siparuna guianensis Aublet

Essential Oil‐Based Biopesticides

Identification of Bioactive Compounds against Aedes aegypti (Diptera: Culicidae) by Bioassays and in Silico Assays

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