Insecticidal activity of some tenuazonic acid analogues

Croix, Eric A. S. la; Mhasalkar, S. E.; Mamalis, P.; Harrington, Frank P.

doi:10.1002/ps.2780060508

Cited by 12 publications

(11 citation statements)

References 10 publications

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“…Thus, A. brassicae produces destruxin B, which has both phytotoxic and insecticidal properties [ 195 , 196 ]. Tenuazonic acid, a phytotoxic mycotoxin of some Alternaria species, showed larvicidal activity against the first-instar larvae of L. sericata (LD 50 120 µg/mL), but was not active against other tested insects and mites from different orders: D. melanogaster , Sitophilus granarius , Aphis fabae , and T. urticae [ 197 ]. At a concentration of 0.06 µg/mL, which is non-toxic both for China rose Rosa chinensis and the rose aphid Macrosiphum rosivorum , tenuazonic acid was able to significantly inhibit the reproduction of this insect, which is presumably associated with the induction of repellents release in leaves treated with this toxin [ 198 , 199 ].…”

Section: Low-molecular-weight Non-volatile Compoundsmentioning

confidence: 99%

The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

Berestetskiy

2021

Microorganisms

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Biorational insecticides (for instance, avermectins, spinosins, azadirachtin, and afidopyropen) of natural origin are increasingly being used in agriculture. The review considers the chemical ecology approach for the search for new compounds with insecticidal properties (entomotoxic, antifeedant, and hormonal) produced by fungi of various ecological groups (entomopathogens, soil saprotrophs, endophytes, phytopathogens, and mushrooms). The literature survey revealed that insecticidal metabolites of entomopathogenic fungi have not been sufficiently studied, and most of the well-characterized compounds show moderate insecticidal activity. The greatest number of substances with insecticidal properties was found to be produced by soil fungi, mainly from the genera Aspergillus and Penicillium. Metabolites with insecticidal and antifeedant properties were also found in endophytic and phytopathogenic fungi. It was noted that insect pests of stored products are mostly low sensitive to mycotoxins. Mushrooms were found to be promising producers of antifeedant compounds as well as insecticidal proteins. The expansion of the number of substances with insecticidal properties detected in prospective fungal species is possible by mining fungal genomes for secondary metabolite gene clusters and secreted proteins with their subsequent activation by various methods. The efficacy of these studies can be increased with high-throughput techniques of extraction of fungal metabolites and their analysis by various methods of chromatography and mass spectrometry.

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Section: Low-molecular-weight Non-volatile Compoundsmentioning

confidence: 99%

The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

Berestetskiy

2021

Microorganisms

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“…Despite a long and detailed synthesis program that succeeded in improving the environmental stability as well as the level of activity, commercially acceptable levels of control have not yet been achieved (40). Similarly, other natural products, including strigol (41), azadirachtin (42), hydantocidin (43), tenuazonic acid (44), ryanodine (45), and many others, have been the targets of numerous structural modification efforts without commercial success. Undoubtedly, continued efforts in one or more of these areas will eventually generate some of the next important classes of pest control agents.…”

Section: Modifying Active Natural Materials: 'Designer" Natural Produmentioning

confidence: 99%

Natural Products as Leads for New Pesticides with Reduced Risks

Crouse¹

1999

ACS Symposium Series

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Although the use of naturally-derived secondary metabolites as pest control agents predates modern agriculture by centuries, technology -driven agricultural practices adapted during the past 50 years curtailed their use in favor of simpler, faster acting and more environmentally stable synthetics. Technological advances are again leading a trend back to naturally-derived materials as the industry learns how to find, optimize, and deliver naturally-derived pest control products. The result will be safer, less environmentally hazardous products for pest control.It seems a natural fit-the best way to control pests is to learn from nature. Organisms are equipped with a broad array of chemical weapons to ward off predators and competitors for limited resources. The use of naturally-derived chemical pest control agents such as nicotine and pyrethrum clearly originated well over a century ago. A limited degree of success was derived from their use, and they were clearly preferable, from a toxicological standpoint, to many of the early chemical treatments based on toxic inorganics or petroleum distillates.Nevertheless, widespread use of naturally occurring pesticides in modern agriculture has remained somewhat limited. As a class, biological control agents account for considerably less than 1% of the overall crop protection market (7). There are a number of good reasons for this. An organism that has no evolutionary pressure to confer such characteristics as photostability, mammalian selectivity or fit in to integrated pest management (IPM), did not build these attributes into its chemical arsenal. As a result, a plant-derived secondary metabolite, such as nicotine, shows little selectivity between insects and mammals. Even a product that is both safe and effective will often encounter difficulties in large scale agricultural applications. Bacillus thuriengensis (Bt), for example, is a family of highly selective proteinaceous Adapted in large part from Crouse, Gary D., CHEMTECH, "Pesticide

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“…The results of ----------- Table III. As seen in Table lIla, the pupation was inhibited by some derivatives of 5-aryltetronic acid (13,15) and the benzylidene compound (21). The mortal effect was not observed in general, but compounds (4) and (8) showed it somewhat.…”

Section: Effect On the Pupation And Emergence Of The Houseflymentioning

confidence: 99%