Insecticidal activity of chemical constituents from <i>Aristolochia pubescens</i> against <i>Anticarsia gemmatalis</i> larvae

Nascimento, Isabele R.; Murata, Afonso Takao; Bortoli, Sérgio Antônio De; Lopes, Lucia Maria Xavier

doi:10.1002/ps.805

Cited by 32 publications

(23 citation statements)

References 11 publications

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“…The biosynthesis, functions, and pharmacological and physiological effects of lignans have been studied, and these compounds have been shown to possess a wide range of biological activities (15,18,23). Lignans have been used as lead compounds for the development of new drugs, mainly due to their low cytotoxicity and their antiangiogenic, antiviral, antileishmanial, antifungal, hypolipidemic, and antirheumatic activities (2).…”

Section: Discussionmentioning

confidence: 99%

Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis

Andrade‐Neto

Silva

Lopes

et al. 2007

Antimicrob Agents Chemother

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Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7R,8S,8S)-3,4-methylenedioxy-4,5-dimethoxy-2,7-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of <0.32 M. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.

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Section: Discussionmentioning

confidence: 99%

Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis

Andrade‐Neto

Silva

Lopes

et al. 2007

Antimicrob Agents Chemother

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“…The potent toxins found in Aristolochia offer promise in specific applications, including antivenom (Abubakar et al 2006;Jimenez-Ferrer et al 2005;Otero et al 2000), antibacterial (Gadhi et al 2001a(Gadhi et al , b, 1999, antifertility (Gupta et al 1996;Pakrashi and Chakrabarty 1978;Pakrashi and Pakrasi 1979), cytotoxic (Hinou et al 1990; Kupchan and Doskotch 1962), antimicrobial or trypanocidal (Abe et al 2002;Elizabeth and Raju 2006;Kumar et al 2006), and insecticidal (Broussalis et al 1999;Jbilou et al 2006;Lajide et al 1993;Nascimento et al 2004). …”

Section: Introductionmentioning

confidence: 97%

Regeneration and plantlet development from somatic tissues of Aristolochia fimbriata

Bliss

Landherr

dePamphilis

et al. 2009

Plant Cell Tiss Organ Cult

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Aristolochia fimbriata is a small herbaceous perennial in the basal angiosperm family Aristolochiaceae. The family contains diverse floral forms ranging from radial to monosymmetric flowers with a wide variety of insect pollinators. Additionally, Aristolochia species contain secondary metabolites that are important natural toxins and traditional medicines, and are critical to the reproduction of swallowtail butterflies. These characteristics, in combination with the small genome size and short life cycle of A. fimbriata, have prompted further development of this species as a model system to study the evolution of basal angiosperms. As a prerequisite for developing a genetic transformation procedure for Aristolochia, we developed protocols for in vitro plant multiplication, shoot organogenesis, rooting, and acclimation of tissue culturederived plants. Two varieties of Aristolochia were multiplied in vitro and rooted with 100% efficiency. Shoot regeneration was achieved within 1 month of culture initiation from whole leaf, internodal stem, and petiole explants. The highest regeneration success (97%) was recorded for stem explants. Regenerated and rooted shoots were acclimated to greenhouse conditions and developed flowers within 4 weeks of transplanting.

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“…Cubebin is a dibenzylbutyrolactone lignan type, which is known to reduce larval viability in Anticarsia gemmatalis to give rise to malformed adult insects (Nascimento et al, 2004), to exhibit antifeedant activity for insect pests (Harmatha and Dinan, 2003), and to show moderate anti-inflammatory and analgesic activities (Silva et al, 2005). Cubebin has been isolated from several species in various families, such as Aristolochiaceae, Myristicaceae, Rutaceae, and Piperaceae (Lopes et al, 2001;Bastos et al, 2001;Koul et al, 1983;Blumenthal et al, 1997).…”

Section: Introductionmentioning

confidence: 99%