Insect-specific viruses and arboviruses in adult male culicids from Midwestern Brazil

Ferreira, Raquel da Silva; Cruz, Lucinéia Claudia de Toni Aquino da; Souza, Vilma Juscineide de; Neves, Nilvanei Aparecido da Silva; Souza, Victor Costa de; Filho, Luciano Chaves Franco; Lemos, Poliana da Silva; Lima, Clayton Pereira Silva de; Naveca, Felipe Gomes; Atanaka, Marina; Nunes, Márcio Roberto Teixeira; Slhessarenko, Renata Dezengrini

doi:10.1016/j.meegid.2020.104561

Cited by 25 publications

(28 citation statements)

References 49 publications

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“…Our database contains only one record in Central and South America, which concerns a single Cx. quinquefasciatus mosquito tested and found positive in Brazil 32 .…”

Section: Discussionmentioning

confidence: 99%

Worldwide transmission and infection risk of mosquito vectors of West Nile, St. Louis encephalitis, Usutu and Japanese encephalitis viruses: a systematic review

Tolsá-García

Wehmeyer

Lühken

et al. 2023

Sci Rep

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The increasing trend of mosquito-borne pathogens demands more accurate global estimations of infection and transmission risks between mosquitoes. Here, we systematically review field and laboratory studies to assess the natural field infection and experimental laboratory transmission risk in Culex mosquitoes. We studied four worldwide flaviviruses: West Nile, Usutu, Japanese encephalitis, and St. Louis encephalitis, belonging to the Japanese encephalitis Serocomplex (JES). The PRISMA statement was carried out for both approaches. The Transmission-Infection Risk of the diverse mosquito species for the different viruses was estimated through seven variables. We considered 130 and 95 articles for field and experimental approach, respectively. We identified 30 species naturally infected, and 23 species capable to transmit some of the four flaviviruses. For the JES, the highest Transmission-Infection Risk estimate was recorded in Culex quinquefasciatus (North America). The maximum Infection-Transmission Risk values for West Nile was Culex restuans, for Usutu it was Culex pipiens (Europe), for St. Louis encephalitis Culex quinquefasciatus (North America), and for Japanese encephalitis Culex gelidus (Oceania). We conclude that on a worldwide scale, a combination of field and experimental data offers a better way of understanding natural infection and transmission risks between mosquito populations.

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“…Our database contains only one record in Central and South America, which concerns a single Cx. quinquefasciatus mosquito tested and found positive in Brazil 32 .…”

Section: Discussionmentioning

confidence: 99%

Worldwide transmission and infection risk of mosquito vectors of West Nile, St. Louis encephalitis, Usutu and Japanese encephalitis viruses: a systematic review

Tolsá-García

Wehmeyer

Lühken

et al. 2023

Sci Rep

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“…Exploring EVEs present in the BSF genome offered additional insights into the virome of BSFs [26,27,79]. The EVE results showed that members of five different viral families which are known to infect insects [63,[80][81][82][83][84][85] have interacted with BSFs in the past. The clustering of HiTV1 among arthropod infecting Totiviridae and its presence across BSFs under different rearing conditions and locations provides strong evidence that BSFs are the natural hosts of this virus.…”

Section: Discussionmentioning

confidence: 99%

First Evidence of Past and Present Interactions between Viruses and the Black Soldier Fly, Hermetia illucens

Pienaar

Gilbert

Belliardo

et al. 2022

Viruses

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Black soldier flies (BSFs, Hermetia illucens) are becoming a prominent research model encouraged by the insect as food and feed and waste bioconversion industries. Insect mass-rearing facilities are at risk from the spread of viruses, but so far, none have been described in BSFs. To fill this knowledge gap, a bioinformatic approach was undertaken to discover viruses specifically associated with BSFs. First, BSF genomes were screened for the presence of endogenous viral elements (EVEs). This led to the discovery and mapping of seven orthologous EVEs integrated into three BSF genomes originating from five viral families. Secondly, a virus discovery pipeline was used to screen BSF transcriptomes. This led to detecting a new exogenous totivirus that we named hermetia illucens totivirus 1 (HiTV1). Phylogenetic analyses showed this virus belongs to a clade of insect-specific totiviruses and is closely related to the largest EVE located on chromosome 1 of the BSF genome. Lastly, this EVE was found to express a small transcript in some BSFs infected by HiTV1. Altogether, this data mining study showed that far from being unscathed from viruses, BSFs bear traces of past interactions with several viral families and of present interactions with the exogenous HiTV1.

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“…aegypti and Ae. albopictus conducted in different geographical areas of the world (Americas, Asia, Africa, Europe, and Australia) [73,107,121,[127][128][129][130][131][132][133][134] have identified that Aedes host a viral community with high diversity. Currently, the available data focus mainly on Ae.…”

Section: Virome In Ae Aegypti and Ae Albopictusmentioning

confidence: 99%

“…aegypti and Ae. albopictus show differences in viral [73,107,128,131,132], related to its high susceptibility to arbovirus infection [23,29,63]. In contrast, the virome of Ae.…”

Section: Virome In Ae Aegypti and Ae Albopictusmentioning

confidence: 99%

Aedes aegypti and Ae. albopictus microbiome/virome: new strategies for controlling arboviral transmission?

et al. 2022

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Aedes aegypti and Aedes albopictus are the main vectors of highly pathogenic viruses for humans, such as dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which cause febrile, hemorrhagic, and neurological diseases and remain a major threat to global public health. The high ecological plasticity, opportunistic feeding patterns, and versatility in the use of urban and natural breeding sites of these vectors have favored their dispersal and adaptation in tropical, subtropical, and even temperate zones. Due to the lack of available treatments and vaccines, mosquito population control is the most effective way to prevent arboviral diseases. Resident microorganisms play a crucial role in host fitness by preventing or enhancing its vectorial ability to transmit viral pathogens. High-throughput sequencing and metagenomic analyses have advanced our understanding of the composition and functionality of the microbiota of Aedes spp. Interestingly, shotgun metagenomics studies have established that mosquito vectors harbor a highly conserved virome composed of insect-specific viruses (ISV). Although ISVs are not infectious to vertebrates, they can alter different phases of the arboviral cycle, interfering with transmission to the human host. Therefore, this review focuses on the description of Ae. aegypti and Ae. albopictus as vectors susceptible to infection by viral pathogens, highlighting the role of the microbiota-virome in vectorial competence and its potential in control strategies for new emerging and re-emerging arboviruses. Graphical Abstract

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Insect-specific viruses and arboviruses in adult male culicids from Midwestern Brazil

Cited by 25 publications

References 49 publications

Worldwide transmission and infection risk of mosquito vectors of West Nile, St. Louis encephalitis, Usutu and Japanese encephalitis viruses: a systematic review

Worldwide transmission and infection risk of mosquito vectors of West Nile, St. Louis encephalitis, Usutu and Japanese encephalitis viruses: a systematic review

First Evidence of Past and Present Interactions between Viruses and the Black Soldier Fly, Hermetia illucens

Aedes aegypti and Ae. albopictus microbiome/virome: new strategies for controlling arboviral transmission?

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