Insect repellents mediate species-specific olfactory behaviours in mosquitoes

Afify, Ali; Potter, Christopher J.

doi:10.1186/s12936-020-03206-8

Cited by 42 publications

(26 citation statements)

References 35 publications

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“…Due to the increasing insecticide resistance levels in malaria vectors, this study aimed to explore Citriodiol ® with its active ingredient PMD as a spatial repellent since it belongs to a different class of chemicals than those currently used in public health. It is a well-known topical repellent [ 24 , 25 , 81 – 84 ] and has been suggested as having spatial repellent properties in a previous study [ 26 ]. However, the previous evaluation was done using electricity-powered active emanators to dispense the chemical.…”

Section: Discussionmentioning

confidence: 99%

Evaluating putative repellent ‘push’ and attractive ‘pull’ components for manipulating the odour orientation of host-seeking malaria vectors in the peri-domestic space

et al. 2021

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Background Novel malaria vector control approaches aim to combine tools for maximum protection. This study aimed to evaluate novel and re-evaluate existing putative repellent ‘push’ and attractive ‘pull’ components for manipulating the odour orientation of malaria vectors in the peri-domestic space. Methods Anopheles arabiensis outdoor human landing catches and trap comparisons were implemented in large semi-field systems to (i) test the efficacy of Citriodiol® or transfluthrin-treated fabric strips positioned in house eave gaps as push components for preventing bites; (ii) understand the efficacy of MB5-baited Suna-traps in attracting vectors in the presence of a human being; (iii) assess 2-butanone as a CO2 replacement for trapping; (iv) determine the protection provided by a full push-pull set up. The air concentrations of the chemical constituents of the push–pull set-up were quantified. Results Microencapsulated Citriodiol® eave strips did not provide outdoor protection against host-seeking An. arabiensis. Transfluthrin-treated strips reduced the odds of a mosquito landing on the human volunteer (OR 0.17; 95% CI 0.12–0.23). This impact was lower (OR 0.59; 95% CI 0.52–0.66) during the push-pull experiment, which was associated with low nighttime temperatures likely affecting the transfluthrin vaporisation. The MB5-baited Suna trap supplemented with CO2 attracted only a third of the released mosquitoes in the absence of a human being; however, with a human volunteer in the same system, the trap caught < 1% of all released mosquitoes. The volunteer consistently attracted over two-thirds of all mosquitoes released. This was the case in the absence (‘pull’ only) and in the presence of a spatial repellent (‘push-pull’), indicating that in its current configuration the tested ‘pull’ does not provide a valuable addition to a spatial repellent. The chemical 2-butanone was ineffective in replacing CO2. Transfluthrin was detectable in the air space but with a strong linear reduction in concentrations over 5 m from release. The MB5 constituent chemicals were only irregularly detected, potentially suggesting insufficient release and concentration in the air for attraction. Conclusion This step-by-step evaluation of the selected ‘push’ and ‘pull’ components led to a better understanding of their ability to affect host-seeking behaviours of the malaria vector An. arabiensis in the peri-domestic space and helps to gauge the impact such tools would have when used in the field for monitoring or control.

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Section: Discussionmentioning

confidence: 99%

Evaluating putative repellent ‘push’ and attractive ‘pull’ components for manipulating the odour orientation of host-seeking malaria vectors in the peri-domestic space

et al. 2021

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“…coluzzii . They argued that the response of mosquitoes to different repellents, and presumably attractants, is species-specific [ 4 ]. We would add that each sex of a mosquito species might also respond differently to odour stimuli, as observed, for example, with foot odour.…”

Section: Discussionmentioning

confidence: 99%

“…For example, eugenol has been shown to be repellent for Ae. Aegypti and Culex quinquefasciatus , but not Anopheles coluzzi [ 4 ]. Within a species, males and females appear to respond to, and share, the same preferences for host plants [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Behavioural Responses of Male Aedes albopictus to Different Volatile Chemical Compounds

Carraretto¹,

Soresinetti²,

Rossi³

et al. 2022

Insects

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The Asian tiger mosquito, Aedes albopictus, has become one of the most important invasive vectors for disease pathogens such as the viruses that cause chikungunya and dengue. Given the medical importance of this disease vector, a number of control programmes involving the use of the sterile insect technique (SIT) have been proposed. The identification of chemical compounds that attract males can be very useful for trapping purposes, especially for monitoring the makeup of the male population during control programmes, such as those involving the use of the SIT. Twenty-eight chemical compounds from different chemical classes were evaluated using a dual-port olfactometer assay. The compounds included known animal, fungal and plant host volatiles, and components of a putative Aedes aegypti pheromone. Many of the compounds were repellent for male mosquitoes, especially at the highest concentration. One compound, decanoic acid, acted as an attractant for males at an intermediate concentration. Decanoic acid did not elicit a significant response from female mosquitoes.

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“…quinquefasciatus show ornithrophilic and zoophilic preference by feeding on humans only occasionally [ 36 , 37 , 38 ]. Afify and Potter [ 39 ] stated correspondingly that different species of mosquitoes have different behavioral responses to repellents. They suggested further that the olfactory systems of anophelinae and culicinae evolved independently and responded differently to odorants, including repellents.…”

Section: Discussionmentioning

confidence: 99%

Ligusticum sinense Nanoemulsion Gel as Potential Repellent against Aedes aegypti, Anopheles minimus, and Culex quinquefasciatus (Diptera: Culicidae)

Junkum

Maleewong

Saeung

et al. 2021

Insects

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Ligusticum sinense Oliv. cv. is a species of Umbelliferae (Apiaceae), a large plant family in the order Apiales. In this study, L. sinense hexane extract nanoemulsion gel (LHE-NEG) was investigated for mosquito repellency and compared to the standard chemical, N,N-diethyl-3-methylbenzamide (DEET), with the goal of developing a natural alternative to synthetic repellents in protecting against mosquito vectors. The results demonstrated that LHE-NEG afforded remarkable repellency against Aedes aegypti, Anopheles minimus, and Culex quinquefasciatus, with median protection times (MPTs) of 5.5 (4.5–6.0), 11.5 (8.5–12.5), and 11.25 (8.5–12.5) h, respectively, which was comparable to those of DEET-nanoemulsion gel (DEET-NEG: 8.5 (7.0–9.0), 12.0 (10.0–12.5), and 12.5 (10.0–13.5) h, respectively). Evaluation of skin irritation in 30 human volunteers revealed no potential irritant from LHE-NEG. The physical and biological stability of LHE-NEG were determined after being kept under heating/cooling cycle conditions. The stored samples of LHE-NEG exhibited some changes in appearance and differing degrees of repellency between those kept for 3 and 6 heating/cooling cycles, thus providing slightly shorter MPTs of 4.25 (4.0–4.5) and 3.25 (2.5–3.5) h, respectively, when compared to those of 5.0 (4.5–6.0) h in fresh preparation. These findings encourage commercially developed LHE-based products as an alternative to conventional synthetic repellents in preventing mosquito bites and helping to interrupt mosquito-borne disease transmission.

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Insect repellents mediate species-specific olfactory behaviours in mosquitoes

Cited by 42 publications

References 35 publications

Evaluating putative repellent ‘push’ and attractive ‘pull’ components for manipulating the odour orientation of host-seeking malaria vectors in the peri-domestic space

Evaluating putative repellent ‘push’ and attractive ‘pull’ components for manipulating the odour orientation of host-seeking malaria vectors in the peri-domestic space

Behavioural Responses of Male Aedes albopictus to Different Volatile Chemical Compounds

Ligusticum sinense Nanoemulsion Gel as Potential Repellent against Aedes aegypti, Anopheles minimus, and Culex quinquefasciatus (Diptera: Culicidae)

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