Insect Repellent Activity of Diterpenoid Alkaloids

Abstract

Diterpenoid and norditerpenoid alkaloids were tested against Tribolium casteneum (Herbst.) in order to assess their repellent activity. Of 29 tested alkaloids, 21 compounds showed promising insect repellent activity, while eight of them were not found to be active. The alkaloids were obtained from Delphinium, Consolida and Aconitum species. The highest activity was found in hetisine, a diterpene alkaloid (59.37%) and the lowest activity in another diterpene alkaloid venulol (31.25%).

Repellency effect of forty-one essential oils against Aedes, Anopheles, and Culex mosquitoes

“…Among 29 tested alkaloids obtained from Delphinium, Consolida, and Aconitum species, 21 compounds showed a promising insect repellent activity, while eight of them were not active. Hetisine had the highest activity while venulol showed the lowest (Ulubelen et al 2001).…”

In vitro activity of C20-diterpenoid alkaloid derivatives in promastigotes and intracellular amastigotes of Leishmania infantum

“…NDAs act as potent nicotinic cholinergic receptor (nAcChR) agonists and antagonists in invertebrates, including insects and in vertebrates [7]. The insecticidal and anti-feedant activity of NDAs [8][9][10], suggest a defensive role played by these compounds. However, only a few DAs have been studied for their plant defensive and pharmacological properties, including their effects on Trypanosoma cruzi epimastigote forms [9,[11][12][13][14][15] and their neurotoxic effects are unknown.…”

Antifeedant C20 Diterpene Alkaloids

“…Furthermore, a recent study on the antifeedant and insecticidal effects of a wide range of structurally-related NDAs support their proposed plantdefensive role [8]. However, only a few DAs have been studied for their pharmacological and plant defensive properties [5] [9 ± 12], and their neurotoxic effects are unknown.…”