Insect pheromones as reversible competitive inhibitors of acetylcholinesterase

Ryan, M. F.; Awde, J.; Moran, Stephen

doi:10.1080/07924259.1992.9672254

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…This compound acted as a competitive inhibitor of AChE (Ki = 1.34 mM), which may explain its neurotoxicity [111]. Ryan and co-workers have previously studied the inhibition of AChE by various insect pheromones: all 17 compounds investigated were reversible competitive inhibitors with Ki values varying between 0.27 and 9.3 mM [163].…”

Section: Ache Inhibitors Of Animal Originmentioning

confidence: 98%

Natural Product Inhibitors of Acetylcholinesterase

Hostettmann¹,

Borloz²,

Urbain³

et al. 2006

COC

135

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Various natural products, such as physostigmine, have long been recognized as inhibitors of the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the treatment of Alzheimer's disease by the blockage of acetylcholine degradation, attempts to find other inhibitors of the enzyme have multiplied, leading to promising candidates such as huperzine A. In this review, a listing is presented of natural product inhibitors, both alkaloid and nonalkaloid in origin. These have been isolated from plant, animal and microbial sources. Details of current testing methods on cholinesterases are given, including solution assays and screening techniques by TLC and HPLC.

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Section: Ache Inhibitors Of Animal Originmentioning

confidence: 98%

Natural Product Inhibitors of Acetylcholinesterase

Hostettmann¹,

Borloz²,

Urbain³

et al. 2006

COC

135

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“…They may singly or jointly contribute to induce toxic effect against mosquito adults [32]. These phytochemicals might be acted like pyrethroid insecticide by deactivating the acetylcholinesterase enzyme leading to the appearance of neurotoxic symptoms such as hyper excitation, convulsion followed by the paralysis and then the insect pest death [33,34]. 100.00±0.00a 500 100.00±0.00a 1000 100.00±0.00a DDVP (1000 mg/bottle) 100.00±0.00a F (5,18) 3480*** Essential oils of C. ambrosoides, H. suaveolens and L. adoensis exhibited also a significant adulticidal activity against the adults of three major vectors mosquito species assessed in the laboratory condition.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, essential oils are complexes of many biologically active constituents such as terpenes, acyclic monoterpene alcohols, monocyclic alcohols, aliphatic aldehydes, aromatic phenols, monocyclic ketones, bicyclic monoterpenic ketones, acids, and esters having biological effects noticed in behavior modification (attraction/repellency) and contact toxicity for insects [38]. Previous works reported pure insecticide compounds, essential oils or pyrethroid insecticides in contact of insects may lead to neurotoxic symptoms such as hyperactivity, seizures and tremors accompanying by knock down effect andthen death of insects [34]. The different compound contained in essential oils may interfere with acetylcholinesterase enzyme acting as potent of the central nervous system where all cholinergic synapses are virtually located, and is responsible of the inhibition action of that enzyme [39].…”

Section: Discussionmentioning

confidence: 99%

Adulticidal Activity of Hyptis suaveolens, Chenopodium ambrosioides and Lippia adoensis Leaf Extracts and Essential Oils against Anopheles gambiae (Diptera: Culicidae)

Oumarou

Younoussa

Langsi

et al. 2021

CJAST

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The study was undertaken to evaluate the adulticidal efficacy of the methanolic leaf extracts and essential oils of Chenopodium ambrosioides, Hyptis suaveolens and Lippia adoensis against adults of Anopheles gambiae. A chemical profile of each plant extracts (qualitative phytochemical screening) and essential oil (GC/MS analysis) was also determined. Doses of 125, 250, 500 and 1000 mg/bottle of plant extracts and 25, 50, 100 and 200 mg/bottle of essential oils were prepared and tested using CDC bottles. In each plant extract, alkaloids, flavonoids, saponins, tannins, phenolic groups, terpenoids, fats and oils were presents. Major chemical constituents of essential oils were thymol (27.09%), sabinene (18.93%) and 4-carene (52.88%) in L. adoensis, H. suaveolens and C. ambrosioides, respectively. L. adoensis extract (at 1000 mg/bottle) and essential oil of H. suaveolens (at 200 mg/bottle) were the most potent causing 100% mortality of An. gambiae adults, 24 h post-exposure. Methanolic extract of L. adoensis (LC50= 20.20 mg/bottle) was the most effective compared to other extracts. Similarly, essential oil of H. suaveolens (LC50= 5.27 mg/bottle) was revealed as the most toxic on An. gambiae adults compared to other oils. Therefore, the extracts of L. adoensis and essential oil of H. suaveolens showed a high activity and should be recommended to be promoting as natural bioinsecticides to control mosquito adults.

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Pheromones

Insect Chemoreception

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Insect pheromones as reversible competitive inhibitors of acetylcholinesterase

Cited by 9 publications

References 9 publications

Natural Product Inhibitors of Acetylcholinesterase

Natural Product Inhibitors of Acetylcholinesterase

Adulticidal Activity of Hyptis suaveolens, Chenopodium ambrosioides and Lippia adoensis Leaf Extracts and Essential Oils against Anopheles gambiae (Diptera: Culicidae)

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