Insect Juvenile Hormone Analogues

Sláma, Karel

doi:10.1146/annurev.bi.40.070171.005243

Cited by 134 publications

(55 citation statements)

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“…Manipulation of JH titer is one of the most common methods employed to understand its mode of action and functions in insects (Sláma, 1971;Howard and Haverty, 1979;Ramaseshadri et al, 2012). The existence of several analogs to JH that both mimic the hormone action and are more stable than the hormone has facilitated experimentation aimed at understanding its function (Robinson, 1985;Robinson and Ratnieks, 1987;Schulz et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Precocene-I inhibits juvenile hormone biosynthesis, ovarian activation, aggression and alters sterility signal production in bumble bee (Bombus terrestris) workers

Amsalem

Teal

Grozinger

et al. 2014

Journal of Experimental Biology

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Juvenile hormone (JH) is an important regulator of development and physiology in insects. While in many insect species, including bumble bees, JH functions as gonadotropin in adults, in some highly eusocial insects its role has shifted to regulate social behavior including division of labor, dominance and aggression. Studying JH functions across social insect species is important for understanding the evolution of sociality; however, these studies have been limited because of the inability to reduce JH levels without surgically removing its glandular source, the corpora allata. Precocene is known to inhibit JH biosynthesis in several non-social insects, but has been poorly studied in social insects. Here, we tested whether precocene-I can effectively reduce JH levels in Bombus terrestris workers, and examined its effects on their physiology and behavior. Precocene-I treatment of three-worker groups decreased JH titer and ovarian activation, irrespective of the bees' dominance rank within the group, and was remedied by JH replacement therapy. Precocene-I also decreased aggressiveness and increased ester-sterility signal production; these changes were rank-dependent, and affected mainly the most reproductive and the least aggressive workers, respectively, and could not be remedied by JH replacement therapy. These results clearly confirm the role of JH as a gonadotropin and mediator of aggression in B. terrestris, and indicate that JH effects are associated with worker dominance rank. The ability to chemically reduce JH titer provides us with a non-intrusive method to probe the evolutionary changes associated with JH and the hormonal mechanisms that are associated with reproduction and behavior in social insects.

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Section: Introductionmentioning

confidence: 99%

Precocene-I inhibits juvenile hormone biosynthesis, ovarian activation, aggression and alters sterility signal production in bumble bee (Bombus terrestris) workers

Amsalem

Teal

Grozinger

et al. 2014

Journal of Experimental Biology

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“…In recent years, the development of cosmetics/cosmeceuticals to prevent melanin overproduction has been accelerated [11]. Insect juvenile hormone is composed of aliphatic terpenes [12]. It has epoxide hydrolase activity, which functions in the biosynthesis of the hormone, and is known to play a key role in metamorphosis [13].…”

Section: Resultsmentioning

confidence: 99%

S-(−)-10,11-Dihydroxyfarnesoic Acid Methyl Ester Inhibits Melanin Synthesis in Murine Melanocyte Cells

Baek

Ahn

Nam

et al. 2014

IJMS

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The development of antimelanogenic agents is important for the prevention of serious aesthetic problems such as melasmas, freckles, age spots, and chloasmas. In the course of screening for melanin synthesis inhibitors, we found that the culture broth from an insect morphopathogenic fungus, Beauveria bassiana CS1029, exhibits potent antimelanogenic activity. We isolated and purified an active metabolite and identified it as S-(−)-10,11-dihydroxyfarnesoic acid methyl ester (dhFAME), an insect juvenile hormone. To address whether dhFAME inhibits melanin synthesis, we first measured the size of the melanin biosynthesis inhibition zone caused by dhFAME. dhFAME also showed inhibitory activity against mushroom tyrosinase in Melan-a cells. Intracellular, dose-dependent tyrosinase inhibition activity was also confirmed by zymography. In addition, we showed that dhFAME strongly inhibits melanin synthesis in Melan-a cells. Furthermore, we compared levels of TYR, TRP-1, TRP-2, MITF, and MC1R mRNA expression by reverse-transcription polymerase chain reaction and showed that treatment of Melan-a cells with 35 μM dhFAME led to an 11-fold decrease in TYR expression, a 6-fold decrease in TRP-2 expression, and a 5-fold decrease in MITF expression. Together, these results indicate that dhFAME is a potent inhibitor of melanin synthesis that can potentially be used for cosmetic biomaterial(s).

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“…[35] JH extract was first extracted from Cecropia moths and its application shown to block larval development. [36] A similar extraction from Tenebrio beetles identified derivatives of farnesol, and JH analogs (JHAs) derived from farnesol and its acid were developed.…”

Section: Juvenile Hormone (Jh) Analogsmentioning

confidence: 99%

Chemosterilants for Control of Insects and Insect Vectors of Disease

Baxter¹

2016

Chimia

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Both historically and at present, vector control is the most generally effective means of controlling malaria transmission. Insecticides are the predominant method of vector control, but the sterile insect technique (SIT) is a complementary strategy with a successful track record in both agricultural and public health sectors. Strategies of genetic and radiation-induced sterilization of Anopheles have to date been limited by logistical and/or regulatory hurdles. A safe and effective mosquito chemosterilant would therefore be of major utility to future deployment of SIT for malaria control. Here we review the prior and current use of chemosterilants in SIT, and assess the potential for future research. Recent genomic and proteomic studies reveal opportunities for specific targeting of seminal fluid proteins, and the capacity to interfere with sperm motility and storage in the female.

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Insect Juvenile Hormone Analogues

Cited by 134 publications

References 0 publications

Precocene-I inhibits juvenile hormone biosynthesis, ovarian activation, aggression and alters sterility signal production in bumble bee (Bombus terrestris) workers

Precocene-I inhibits juvenile hormone biosynthesis, ovarian activation, aggression and alters sterility signal production in bumble bee (Bombus terrestris) workers

S-(−)-10,11-Dihydroxyfarnesoic Acid Methyl Ester Inhibits Melanin Synthesis in Murine Melanocyte Cells

Chemosterilants for Control of Insects and Insect Vectors of Disease

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