Inscribing the core memories of killers

Abstract

Inscribing the core memories of killers SJ Dulson et al.

Trispecific killer engager 161519 enhances natural killer cell function and provides anti-tumor activity against CD19-positive cancers

“…The overall structures of 161519 TriKE in our study and the one designed previously 20 were identical. However, the anti-CD16 and anti-CD19 antibody sequences 16 , 23 used in our study were different from the ones used previously 25 , 26 . In addition, our study used in vivo models to show that 161519 TriKE promoted the proliferation and survival of human NK cells and mediated stronger anti-tumor responses compared with that by 1619 BiKE.…”

“…Cold tumors are immunologically ignorant and express minimal or no MHC class-I molecules on the cell surface 7 . They are barely recognized by CD8 + T cells due to the missing/impaired expression of MHC class-I molecules, but they can be detected readily and targeted by NK cells 8 , 9 , 23 . The 161519 TriKE constructed in our studies was a trispecific protein developed for the treatment of B-cell malignancies (CD19-positive cancers) and was designed to redirect NK cells via their activating receptor CD16 to kill target cells expressing CD19.…”