Input rate encoding and gain control in dendrites of neocortical pyramidal neurons

Dembrow, Nikolai C.; Spain, William J.

doi:10.1016/j.celrep.2022.110382

Cited by 11 publications

(8 citation statements)

References 101 publications

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“…We replicated this experiment with a cluster of 18 synapses at 100 μm, which was sufficient to create an NMDA spike. (We note that it is possible to create an NMDA spike with fewer clustered synapses if the synapses are activated at a high frequency [55,56]. In this and subsequent simulations, for simplicity, we vary only the number of synapses and use a single presynaptic spike at each cluster to create an NMDA spike; cluster size here thus serves as a convenient single-variable measure of input strength.)…”

Section: Resultsmentioning

confidence: 99%

“…We replicated this experiment with a cluster of 18 synapses at 100 μm from the soma, which was sufficient to generate an NMDA spike in these spines (see also (Eyal, Verhoog, Testa-Silva, Deitcher, Benavides-Piccione, et al, 2018)). (We note that it is possible to create an NMDA spike with fewer clustered synapses if the synapses are activated at a high frequency (Dembrow & Spain, 2022; Polsky et al, 2009), however in this work, for simplicity, we only vary the cluster size.) The same asymmetric effect as described above was qualitatively observed for the NMDA spike; voltage attenuation was very minor from the activation site to the distal tip and very substantial from the activation site toward the soma (Figure 2B-C).…”

Section: Resultsmentioning

confidence: 99%

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Asymmetric voltage attenuation in dendrites can enable hierarchical heterosynaptic plasticity

Moldwin

Kalmenson

Segev

2022

Preprint

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Long-term synaptic plasticity has been shown to be mediated via calcium concentration ([Ca2+]). Using a synaptic model which implements calcium-based long-term plasticity via two sources of Ca2+, NMDA receptors and voltage-gated calcium channels (VGCCs), we show in dendritic cable simulations that the interplay between these two calcium sources can result in a diverse array of heterosynaptic effects. When spatially clustered synaptic input produces an NMDA spike, the resulting dendritic depolarization can activate VGCCs at other spines, resulting in heterosynaptic plasticity. Importantly, NMDA spike activation at a given dendritic location will tend to depolarize dendritic regions that are located distally to the input site more than dendritic sites that are proximal to it. This dendritic asymmetry results in a hierarchical heterosynaptic plasticity effect in branching dendrites, where clustered inputs to a proximal branch induce heterosynaptic plasticity primarily at branches that are distal to it. We also explore how simultaneously activated synaptic clusters located at different dendritic locations synergistically affect each other as well as the heterosynaptic plasticity of an inactive synapse "sandwiched" between them. We conclude that dendrites enable a sophisticated form of plastic supervision wherein NMDA spike induction can be spatially targeted to produce plasticity at specific dendritic regions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Asymmetric voltage attenuation in dendrites can enable hierarchical heterosynaptic plasticity

Moldwin

Kalmenson

Segev

2022

Preprint

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“…Previous studies on spatial integration mainly focused on fully clustered (Carter et al, 2007 ; Gökçe et al, 2016 ; Dembrow and Spain, 2022 ) or fully dispersed (Farinella et al, 2014 ) synaptic inputs, without paying attention to the intermediate state, which is difficult to realize in the experiment, thus hindering understanding of the specific connection mode in the brain. Recently, supralinear and sublinear integration coexisting(bi-modal integration) on the same dendrite of FS BCs has been reported (Tzilivaki et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Spatial integration of dendrites in fast-spiking basket cells

Liu

Sun

2023

Front. Neurosci.

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Dendrites of fast-spiking basket cells (FS BCs) impact neural circuit functions in brain with both supralinear and sublinear integration strategies. Diverse spatial synaptic inputs and active properties of dendrites lead to distinct neuronal firing patterns. How the FS BCs with this bi-modal dendritic integration respond to different spatial dispersion of synaptic inputs remains unclear. In this study, we construct a multi-compartmental model of FS BC and analyze neuronal firings following simulated synaptic protocols from fully clustered to fully dispersed. Under these stimulation protocols, we find that supralinear dendrites dominate somatic firing of FS BC, while the preference for dispersing is due to sublinear dendrites. Moreover, we find that dendritic diameter and Ca2+-permeable AMPA conductance play an important role in it, while A-type K+ channel and NMDA conductance have little effect. The obtained results may give some implications for understanding dendritic computation.

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“…The role of these dendritic spikes is thought to be in modulating the gain of the soma-based input-output function [21]. Other efforts have established an additive modulation by dendritic inputs that have been transformed nonlinearly as in an artificial neural network [22][23][24][25][26] (with possibly nonmonotonic activation functions [27,28]). However, both the additive and gain modulations are thought to be weak in the presence of background fluctuations [21,24].…”

Section: Introductionmentioning

confidence: 99%

Dendritic excitability controls overdispersion

Friedenberger

Naud

2022

Preprint

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A neuron's input-output function is commonly understood in terms of the fluctuation-driven and mean-driven regimes. Here we investigate how active dendrites falling in either regime shape the input-output function and find that dendritic input primarily controls interspike interval dispersion, a prediction that is validated with dual patch clamp recordings. This phenomenon can be understood by considering that neurons display not two, but three fundamental operating regimes, depending on whether dendritic spikes or the somatic input reach threshold.

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Input rate encoding and gain control in dendrites of neocortical pyramidal neurons

Cited by 11 publications

References 101 publications

Asymmetric voltage attenuation in dendrites can enable hierarchical heterosynaptic plasticity

Asymmetric voltage attenuation in dendrites can enable hierarchical heterosynaptic plasticity

Spatial integration of dendrites in fast-spiking basket cells

Dendritic excitability controls overdispersion

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