“…It is unlikely that an N400-based SIN thresholding process will be realized in the clinic so long as the N400 must be derived using conventional signal averaging. If, however, the the single trial approach to ERP detection that is used for brain-computer interfaces (e.g., Boutani & Ohsuga, 2012;Chen, Guan, & Liu, 2011;Guo, Gao, Modulation of Passive N400 by SNR 27 & Hong, 2010;Heinrich, Dickhaus, Rothenberger, Heinrich, & Moll, 1999;Iyer & Zouridakis, 2007;Zou, Zhang, Yang, & Zhou, 2010) advances to the point of clinical utility, this may become a possibility. In the absence of such innovations, testing at a single level and using the electrophysiological response as a predictor of the SNR50, as in ongoing research using the N1 (Billings et al, 2013;Billings et al, 2015), is one among a variety of conceivable practical approaches to reduce the length of the test while using signal-averaging.…”