INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1–mediated lysosomal exocytosis
Golam T. Saffi,
Lydia To,
Nicholas Kleine
et al.
Abstract:Aggressive solid malignancies, including pancreatic ductal adenocarcinoma (PDAC), can exploit lysosomal exocytosis to modify the tumor microenvironment, enhance motility, and promote invasiveness. However, the molecular pathways through which lysosomal functions are co-opted in malignant cells remain poorly understood. In this study, we demonstrate that inositol polyphosphate 4-phosphatase, Type II (INPP4B) overexpression in PDAC is associated with PDAC progression. We show that INPP4B overexpression promotes … Show more
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