Inpatients versus outpatients with advanced non-small cell lung cancer: Characteristics and outcomes

Gotfrit, Joanna; Jonker, Caleb; Zhang, Tinghua; Goss, Greg G.; Nicholas, Garth; Laurie, Scott A.; Wheatley‐Price, Paul

doi:10.1016/j.ctarc.2019.100130

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…However, the current diagnosis and treatment methods for NSCLC are limited, and the therapeutic effect is still far from satisfactory. 25–28 MALAT1 and PD-L1 promote NSCLC progression, while multiple miR-200 family members play a role in fighting it. 29–36 Consistent with previous reports, we found that MALAT1 and PD-L1 were highly expressed in NSCLC, while miR-200a-3p was significantly downregulated.…”

Section: Discussionmentioning

confidence: 99%

LncRNA MALAT1 contributes to non-small cell lung cancer progression via modulating miR-200a-3p/programmed death-ligand 1 axis

Wei

Wang

Huang

et al. 2019

Int J Immunopathol Pharmacol

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This study was to investigate the expression correlation between long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1), miR-200a-3p and programmed death-ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC), and their roles in NSCLC. Real-time polymerase chain reaction (PCR) was performed to detect the expressions of MALAT1, miR-200a-3p and PD-L1 in NSCLC tissues and cells for the correlation analysis. The starBase and Targetscan databases were used to predict the binding sites between MALAT1 and miR-200a-3p, and miR-200a-3p and PD-L1, respectively. The targeting relationship between MALAT1 and miR-200a-3p, and miR-200a-3p and PD-L1 were further verified by real-time PCR and dual luciferase reporter gene assay. Cell proliferation was monitored by CCK8 and colony formation assays. The apoptosis was detected using flow cytometry. Wound healing assay and transwell assay were conducted to determine cell migration and invasion. In this study, we demonstrated that in NSCLC tissues, the expression level of MALAT1 was negatively correlated with that of miR-200a-3p, while positively correlated with PD-L1. Besides, MALAT1 promoted proliferation, mobility, migration, and invasion of NSCLC cells via sponging miR-200a-3p. PD-L1 was validated as a target of miR-200a-3p, and indirectly modulated by MALAT1. In conclusion, LncRNA MALAT1 facilitates the progression of NSCLC by modulating miR-200a-3p/PDL1 axis.

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Section: Discussionmentioning

confidence: 99%

LncRNA MALAT1 contributes to non-small cell lung cancer progression via modulating miR-200a-3p/programmed death-ligand 1 axis

Wei

Wang

Huang

et al. 2019

Int J Immunopathol Pharmacol

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“…In other branches of medicine and in a similar fashion, hypercalcemia in admitted patients indicated malignancy while benign causes are expected in ambulatory patients [24]. Similarly, admission status is an indicator of poor prognosis in patients diagnosed with lung cancer, lymphoma, and uterine cervical neoplasia during their hospital stay when compared to outpatients [25][26][27]. These examples are abundant and widely reproduced; however, the biological mechanisms by which co-morbidities contribute to the pathogenesis of high-risk neoplasia remain to be elucidated.…”

Section: Discussionmentioning

confidence: 95%

Serum Chloride and Admission Status Are Potential Prognostic Markers of High-Risk Polyps: A Prospective Characterization of Colorectal Polyps in a Tertiary Hospital in Saudi Arabia

Algassim¹,

Semaan²,

Aldaher³

et al. 2022

Cureus

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Background: Colorectal cancer (CRC) is the most common cancer in men in Saudi Arabia. Other than age and family history, clinical and laboratory prognostic surrogates that may aid in streamlining and prioritization of screening colonoscopies are scarce. Through the examination of the local prevalence of advanced and malignant colorectal polyps, we hypothesized that the presence of certain clinical or laboratory parameters may signify an association with having high-risk polyps.Methods: A prospective study over a period of one year starting on January 21, 2018 and involving all adult patients undergoing colonoscopy at King Saud Medical City, Riyadh. Of the total 1,104 recruited patients, 717 were included. The patients were sub-grouped based on the presence or absence of polyps. Patients with polyps were further sub-grouped into high-risk or low-risk polyps. Comparisons between groups were performed using univariate, relative risks (RRs), and multivariate analyses.Results: Our polyp detection rate was 34.7% and our adenoma detection rate was 21.3%. The prevalence of advanced adenoma was 15.2% and the prevalence of malignant polyps was 6.7%. Several prognostic markers were associated with high-risk polyps such as advanced age (RR = 1.35, 95% confidence interval [CI]: 1.03 to 1.78), male gender (RR = 1.18, 95% CI: 1.06 to 1.31), inpatient status (RR = 1.46, 95% CI: 1.04 to 2.21), and low serum chloride (RR = 1.89, 95% CI: 1.05 to 2.37). With multivariate analysis, the hazard ratios for inpatient status and hypochloremia were 1.67 (95% CI: 1.034 to 2.612) and 1.12 (95% CI: 1.011 to 1.265), respectively. Conclusion:We report the prevalence of malignant colorectal polyps in Saudi Arabia which was not reported before. Two unique prognostic markers for high-risk polyps were identified, namely, inpatient status and hypochloremia.

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“…Additionally, the reason why our participants had a lower level of symptoms than those in Seo and Park’s study is that the severity of disease in the two studies were different; for the most part, ours were patients with Stage II disease, whereas most of their patients were Stage IV. Compared with outpatients, inpatients need continuous pain control due to the rapid onset of symptoms, and the severity of symptoms in some terminally ill inpatients is so high (Gotfrit et al, 2019). The prevalent symptoms in this study were fatigue, drowsiness, and dry mouth, which were similar to the findings of another study (Wang & Fu, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, an increase in symptoms significantly increases a patient's care needs. Most lung cancer patients in hospital receive palliative care when their terminal condition progresses rapidly (Gotfrit et al, 2019). Outpatients too can experience severe symptoms (Reinke et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Factors Related to the Caregiving Burden on Families of Korean Patients With Lung Cancer

Lee

Park

2022

Clin Nurs Res

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The purposes of this study were to describe caregiver burden on families of patients with lung cancer and to examine its associated factors, including patient symptoms and symptom clusters. In this cross-sectional study, 120 patient-caregiver dyads were recruited from an outpatient clinic in a tertiary care hospital. Patient symptoms and caregiver burden were measured with structured questionnaire. Descriptive and inferential statistics were used to analyze data. Three patient symptom clusters were identified. Hierarchical regression showed that a patient’s smoking history; caregiver age, education, health status, depression, social support, monthly family income, relationship with patient, and time spent on nursing each day; and presence of another caregiver explained 41.4% of the total variance in caregiver burden. When patient symptom clusters were added to regression model, change in total variance in caregiver burden was significant. To reduce their burden, caregivers should be taught how cancer progresses and its major symptoms after chemotherapy.

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Inpatients versus outpatients with advanced non-small cell lung cancer: Characteristics and outcomes

Cited by 7 publications

References 14 publications

LncRNA MALAT1 contributes to non-small cell lung cancer progression via modulating miR-200a-3p/programmed death-ligand 1 axis

LncRNA MALAT1 contributes to non-small cell lung cancer progression via modulating miR-200a-3p/programmed death-ligand 1 axis

Serum Chloride and Admission Status Are Potential Prognostic Markers of High-Risk Polyps: A Prospective Characterization of Colorectal Polyps in a Tertiary Hospital in Saudi Arabia

Factors Related to the Caregiving Burden on Families of Korean Patients With Lung Cancer

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