“…In a meta-analysis of three randomized, placebo-controlled trials involving femoral and posterior lumbar plexus catheters for TKA and total hip arthroplasty, respectively, Ilfeld et al found that no subjects receiving perineural saline (n = 86) fell (0%) while there were seven falls (7%) in patients receiving perineural ropivacaine (n = 85; p = 0.01), strongly suggesting a causal relationship between the continuous blocks and falling. 3 Since there were no falls in the placebo group, an odds ratio cannot be calculated; but, if even just a single fall occurred in this group, the odds ratio would be 5.5 (therefore, the actual odds ratio is at least 5.5, but possibly higher). Finally, an additional metaanalysis including 4 randomized, controlled trials and one retrospective cohort study, Johnson et al calculated an odds ratio of 3.9 (p < 0.01) of falling for subjects with a continuous femoral or posterior lumbar plexus block of greater than 12 h (incidence = 2.2%) compared with subjects with either no block, a single-injection block, or a perineural infusion of less than 12 h (incidence = 0.5%).…”