Inositol - An effective growth promotor?

Lee, S.A.; Bedford, M.R.

doi:10.1017/s0043933916000660

Cited by 56 publications

(28 citation statements)

References 90 publications

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“…This is in contrast to P, which also is released during phytate degradation and is known for its end-product inhibition effects on phytate degradation (Greiner et al, 1993 ; Angel et al, 2002 ; Olukosi and Fru-Nji, 2014 ; Shastak et al, 2014 ; Zeller et al, 2015b ). As reviewed by Lee and Bedford ( 2016 ), MI is thought to be involved in bone formation and bone mineral density in mice. This was not supported by the tibia ash data obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…However, no effects of MI supplementation on broiler performance were found in a study using a different broiler strain than that used in the present study (Linares et al, 2017 ). MI is involved in several signaling pathways that play roles in cell survival and growth, lipid metabolism, and insulin sensitivity (Huber, 2016 ; Lee and Bedford, 2016 ). Although the numerically low increase in G:F owing to the supplementation of MI was highly significant, further studies should be conducted to confirm this outcome and to investigate the metabolic mode of action of MI in the animal.…”

Section: Discussionmentioning

confidence: 99%

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Influence of phytase or myo-inositol supplements on performance and phytate degradation products in the crop, ileum, and blood of broiler chickens

et al. 2018

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The objective of this study was to investigate the effects of supplementation with free myo-inositol (MI) or graded levels of phytase on inositol phosphate (InsP) degradation, concentrations of MI in the digestive tract and blood, bone mineralization, and prececal digestibility of amino acids (AA). Ross 308 broiler hatchlings were allocated to 40 pens with 11 birds each and assigned to one of 5 treatments. The birds were fed a starter diet until d 11 and a grower diet from d 11 to d 22. All diets were based on wheat, soybean meal, and corn. Birds were fed a control diet, calculated to contain adequate levels of all nutrients without (C) or with MI supplementation (C+MI), or one of 3 experimental diets that differed in phytase level (modified E. coli-derived 6-phytase; Phy500, Phy1500, or Phy3000 FTU/kg), with P and Ca levels adapted to the recommendations of the phytase supplier for a phytase level of 500 FTU/kg. The gain:feed ratio (G:F) was increased by MI or phytase in the starter+grower phase by 0.02 g/g. Prececal P and Ca digestibility, P and Ca concentration in blood serum, and tibia ash weight did not differ among treatments (P > 0.05). MI supplementation led to the highest MI concentration in the crop, ileum, and blood plasma across treatments. Phytase supplementation increased MI concentrations in the crop and ileum digesta in a dose-dependent manner and in plasma without any dose effect (P > 0.05). Prececal digestibility of some AA was increased by phytase. These outcomes indicate that MI might have been a relevant cause for the increase in G:F. Therefore, it is likely that the release of MI after complete dephosphorylation of phytate is one of the beneficial effects of phytase, along with the release of P and improvement in digestibility of other nutrients. Simultaneously, MI seems to have no diminishing effects on InsP degradation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of phytase or myo-inositol supplements on performance and phytate degradation products in the crop, ileum, and blood of broiler chickens

et al. 2018

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“…An improvement in FCR with xylanase addition was not seen when phytase was added at 1500 FTU/kg phytase. Super-dose levels of phytase are receiving more and more attention as high levels of phytase liberate more available P, energy and amino acids (Cowieson, Wilcock, and Bedford 2011), increase mineral bioavailability (Kies et al 2006), reduce phytate, thus reducing its anti-nutritional effect and increase myo-inositol (Lee and Bedford 2016;Woyengo, Weihrauch, and Nyachoti 2012) which has been shown to have numerous beneficial effects (Zyla et al 2004;Cowieson et al 2013). Feed conversion ratio was low and similar for super-dose levels of phytase irrespective of xylanase level suggesting that the super-dose level improved feed efficiency, thus there was no further scope for improvement with the addition of xylanase.…”

Section: Discussionmentioning

confidence: 99%

The effects of phytase and xylanase supplementation on performance and egg quality in laying hens

Taylor

Bedford

Pace

et al. 2018

British Poultry Science

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1. The aim of this study was to evaluate the effects of phytase and xylanase and their interaction on laying hen performance, egg quality, phosphorus (P) digestibility, phytate breakdown, volatile fatty acid (VFA) production and peptide YY concentration. 2. Two hundred and forty hens were allocated to cages at 22 weeks of age based on a 3 × 2 arrangement with phytase (0, 300 or 1500 FTU/kg) and xylanase (0 or 12 000 BXU/kg) as factors. 3. Phytase increased hen-day production (P < 0.05), daily egg mass (P < 0.05) and P digestibility with increasing levels of phytase (P < 0.001). Phytase fed at 1500 FTU/kg reduced IP6 and IP5 and increased myo-inositol concentration in gizzard digesta (P < 0.05). Phytase fed at 300 FTU/kg reduced IP6 in ileal digesta (P < 0.05); however, IP6 and IP5 were further reduced and myo-inositol increased when phytase was added at 1500 FTU/kg (P < 0.05). 4. Xylanase improved feed efficiency when phytase was fed at 300 FTU/kg (P < 0.05). In the absence of phytase, xylanase reduced dry matter and Ca digestibilities (P < 0.05). 5. Neither phytase nor xylanase had an effect on peptide YY or caecal VFA concentrations.

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“…For what concern feed additives, the administration of phytase in broiler diet is reported to have a direct effect on organic phosphorus (phytate) and mineral digestibility, but also an indirect effect on zootechnical performance and muscle development mainly through the release of myo-inositol [ 91 , 92 ]. Schmeisser et al [ 93 ] reported that the administration of a 6-microbial phytase in a moderately phosphorous-deficient diet determined significant changes in the expression levels of genes involved in muscle development through calmodulin/calcineurin and insulin-like growth factor pathways.…”

Section: Nutritionmentioning

confidence: 99%

Application of omics technologies for a deeper insight into quali-quantitative production traits in broiler chickens: A review

Zampiga

Flees

Meluzzi

et al. 2018

J Animal Sci Biotechnol

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The poultry industry is continuously facing substantial and different challenges such as the increasing cost of feed ingredients, the European Union’s ban of antibiotic as growth promoters, the antimicrobial resistance and the high incidence of muscle myopathies and breast meat abnormalities. In the last decade, there has been an extraordinary development of many genomic techniques able to describe global variation of genes, proteins and metabolites expression level. Proper application of these cutting-edge omics technologies (mainly transcriptomics, proteomics and metabolomics) paves the possibility to understand much useful information about the biological processes and pathways behind different complex traits of chickens. The current review aimed to highlight some important knowledge achieved through the application of omics technologies and proteo-genomics data in the field of feed efficiency, nutrition, meat quality and disease resistance in broiler chickens.

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Inositol - An effective growth promotor?

Cited by 56 publications

References 90 publications

Influence of phytase or myo-inositol supplements on performance and phytate degradation products in the crop, ileum, and blood of broiler chickens

Influence of phytase or myo-inositol supplements on performance and phytate degradation products in the crop, ileum, and blood of broiler chickens

The effects of phytase and xylanase supplementation on performance and egg quality in laying hens

Application of omics technologies for a deeper insight into quali-quantitative production traits in broiler chickens: A review

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