Inorganic pharmaceuticals

Holder, Alvin A.

doi:10.1039/c2ic90009b

Cited by 10 publications

(4 citation statements)

References 210 publications

(180 reference statements)

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“…Such metal ions are present in several inorganic pharmaceuticals used as drugs against a variety of diseases ranging from antimicrobial to anticancer applications. [ 44 ] Also, these metal ions are inexpensive compared to other elements such as Ru (II) and Pt (II) as example.…”

Section: Introductionmentioning

confidence: 99%

Characterization, theoretical computation, DNA‐binding, molecular docking, antibacterial, and antioxidant activities of new metal complexes of (E)‐1‐([1H‐1,2,4‐triazol‐3‐yl]diazenyl)naphthalen‐2‐ol

El-Sayed

Gaber

Fahmy

et al. 2022

Applied Organom Chemis

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Complexes of (E)-1- ([1H-1,2,4-triazol-3-yl]diazenyl)naphthalen-2-ol with manganese (II), cobalt (II), nickel (II), and zinc (II) have been constructed. Elemental analyses, molar conductance, magnetic moment measurements, spectral (IR, 1 H, 13 C NMR, EI-mass, and UV-Vis), XRD, and thermal studies have all been used to determine the structure of complexes. Except for Ni (II), which has a tetrahedral geometry, the results demonstrated that all complexes have octahedral geometry. The molecular mechanic calculations used in the hyper chem. 8.03 molecular modeling program were used to determine the potential structures of metal complexes. To confirm the geometrical geometries of the investigated metal complexes, the bond lengths, bond angles, LUMO, HOMO, and dipole moments of the listed complexes were determined. At varied heating rates, the thermal analysis (TG) measurements are also investigated.Different integral equations were used to compute the kinetic and thermodynamic characteristics of the thermal degradation processes. UV-Vis absorption titration was used to study the complexes' DNA binding mechanisms. The results revealed that the complexes attach to DNA in either intercalative or non-intercalative manner. Azodye and its metal complexes were tested in vitro against Gram positive bacteria (Staphylococcus aureus), Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa), fungi (Aspergillus flavus, Candida albicans, and Mucor), and yeast (Malassezia furfur). The azodye and its metal chelates have shown potent antioxidant activities. The molecular docking analysis has been tested with Topoisomerase II protein code: 4CHT model.

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Section: Introductionmentioning

confidence: 99%

Characterization, theoretical computation, DNA‐binding, molecular docking, antibacterial, and antioxidant activities of new metal complexes of (E)‐1‐([1H‐1,2,4‐triazol‐3‐yl]diazenyl)naphthalen‐2‐ol

El-Sayed

Gaber

Fahmy

et al. 2022

Applied Organom Chemis

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“…Heavy metals are toxic and tend to accumulate in the food chain and can cause severe health problems [1,2]. Accumulation is enhanced by the tendency of heavy metals to form complexes with biological matter [3][4][5]. Ingestion of cadmium, arsenic, vanadium and lead above the tolerance levels have been linked to kidney [6][7][8], DNA damage [9,10], cancer [4,5,11], brain damage [4,12], obstructing of protein and oxidation of lipids, which lead to the development of cardiovascular diseases [7,13,14].…”

Section: Introductionmentioning

confidence: 99%

A review of cryogels synthesis, characterization and applications on the removal of heavy metals from aqueous solutions

Baimenov

Berillo

Poulopoulos

et al. 2020

Advances in Colloid and Interface Science

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“…They are most abundantly found trace elements present in biological systems together with iron and most of the metalloproteins have these elements [30][31][32][33]. These metal ions are nowadays present in several inorganic pharmaceuticals used as drugs against a variety of diseases, ranging from antibacterial and antifungal to anticancer applications [34][35][36][37][38][39][40][41]. In addition to that, the N-heterocycles, pyrazolones and quinazolinone derivatives as ligands affect the environment of the complex in such a way that their lipophilicity increases which is a major factor in designing a drug [42][43][44][45][46][47][48][49][50][51][52][53].…”

Section: Introductionmentioning

confidence: 99%

Metal Complexes as Potential Antimicrobial Agent: A Review

Hossain¹

2018

AJHC

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Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review our main focused on research undertaken over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-inflammatory, anti-cancer, DNA-interaction and anti-tumor action of synthetic metal complexes.

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Inorganic pharmaceuticals

Cited by 10 publications

References 210 publications

Characterization, theoretical computation, DNA‐binding, molecular docking, antibacterial, and antioxidant activities of new metal complexes of (E)‐1‐([1H‐1,2,4‐triazol‐3‐yl]diazenyl)naphthalen‐2‐ol

Characterization, theoretical computation, DNA‐binding, molecular docking, antibacterial, and antioxidant activities of new metal complexes of (E)‐1‐([1H‐1,2,4‐triazol‐3‐yl]diazenyl)naphthalen‐2‐ol

A review of cryogels synthesis, characterization and applications on the removal of heavy metals from aqueous solutions

Metal Complexes as Potential Antimicrobial Agent: A Review

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