Inorganic Nanoparticles as Free Radical Scavengers

Fifere, Adrian; Moleavin, Ioana-Andreea Turin; Lungoci, Ana-Lacramioara; Marangoci, Narcisa; Pinteală, Mariana

doi:10.1007/978-3-030-57456-7_15

Cited by 1 publication

(2 citation statements)

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Section: Redox Properties Of Inorganic Nanoparticlesmentioning

confidence: 99%

“…Inorganic nanoparticles behave as redox-potent agents using an important variety of mechanisms which are depicted in Figure 3. For a detailed view of this chemistry, the reader is referred to the following reviews [48][49][50][51][52][53]. Nanoparticles interfere with the redox homeostasis of a medium via different pathways: either directly, e.g., by providing electrons for the direct self-conversion of an antioxidant to a prooxidant molecule and vice versa [54], or indirectly, e.g., by the nanoparticle degradation via dissolution [55] or upon radiation [56].…”

Section: Redox Properties Of Inorganic Nanoparticlesmentioning

confidence: 99%

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Inorganic Nanoparticles: Tools to Emphasize the Janus Face of Amphotericin B

Boudier,

Mammari,

Lamouroux

et al. 2023

Antibiotics

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Amphotericin B is the oldest antifungal molecule which is still currently widely used in clinical practice, in particular for the treatment of invasive diseases, even though it is not devoid of side effects (particularly nephrotoxicity). Recently, its redox properties (i.e., both prooxidant and antioxidant) have been highlighted in the literature as mechanisms involved in both its activity and its toxicity. Interestingly, similar properties can be described for inorganic nanoparticles. In the first part of the present review, the redox properties of Amphotericin B and inorganic nanoparticles are discussed. Then, in the second part, inorganic nanoparticles as carriers of the drug are described. A special emphasis is given to their combined redox properties acting either as a prooxidant or as an antioxidant and their connection to the activity against pathogens (i.e., fungi, parasites, and yeasts) and to their toxicity. In a majority of the published studies, inorganic nanoparticles carrying Amphotericin B are described as having a synergistic activity directly related to the rupture of the redox homeostasis of the pathogen. Due to the unique properties of inorganic nanoparticles (e.g., magnetism, intrinsic anti-infectious properties, stimuli-triggered responses, etc.), these nanomaterials may represent a new generation of medicine that can synergistically enhance the antimicrobial properties of Amphotericin B.

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