Inorganic nanoparticle-based contrast agents for molecular imaging

Cho, Eun Chul; Glaus, Charles; Chen, Jingyi; Welch, Michael J.; Xia, Younan

doi:10.1016/j.molmed.2010.09.004

Cited by 223 publications

(147 citation statements)

References 125 publications

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“…NIR irradiation allows maximal light penetration into the tissue and image formation is based on the differences in absorption-scattering profiles of the medium. OCT imaging has high spatial resolution in the micrometer range with a penetration depth in the low millimeter range [39]. GNRs have been also used for OCT imaging of cancer.…”

Section: Biomedical Imaging Of Gnrsmentioning

confidence: 99%

Applications of gold nanorods in biomedical imaging and related fields

Hong-xing

Liu

et al. 2013

Chin. Sci. Bull.

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Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered.

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Section: Biomedical Imaging Of Gnrsmentioning

confidence: 99%

Applications of gold nanorods in biomedical imaging and related fields

Hong-xing

Liu

et al. 2013

Chin. Sci. Bull.

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“…Size control could be reached by the decomposition of organometallic precursors at high temperature in the presence of long alkyl chain surfactants [34,35], further synthesis information being found in recent review articles [36,37]. Concerning magnetic dopants, they can be added in the spinel structure by co-reduction at high temperature of organometallic precursors, such as Mn(acac) 2 and Fe(acac) 3 [38].…”

Section: Synthesis Of Magnetic Nanoparticlesmentioning

confidence: 99%

New generation of magnetic and luminescent nanoparticles for in vivo real-time imaging

et al. 2013

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One contribution of 10 to a Theme Issue 'Molecular-, nano-and micro-devices for real-time in vivo sensing'. A new generation of optimized contrast agents is emerging, based on metallic nanoparticles (NPs) and semiconductor nanocrystals for, respectively, magnetic resonance imaging (MRI) and near-infrared (NIR) fluorescent imaging techniques. Compared with established contrast agents, such as iron oxide NPs or organic dyes, these NPs benefit from several advantages: their magnetic and optical properties can be tuned through size, shape and composition engineering, their efficiency can exceed by several orders of magnitude that of contrast agents clinically used, their surface can be modified to incorporate specific targeting agents and antifolding polymers to increase blood circulation time and tumour recognition, and they can possibly be integrated in complex architecture to yield multi-modal imaging agents. In this review, we will report the materials of choice based on the understanding of the basic physics of NIR and MRI techniques and their corresponding syntheses as NPs. Surface engineering, water transfer and specific targeting will be highlighted prior to their first use for in vivo realtime imaging. Highly efficient NPs that are safer and target specific are likely to enter clinical application in a near future.

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“…Cho et al (31) investigated inorganic nanoparticles containing semiconductor quantum dots, iron oxide and gold, which revealed their potential for use as contrast agents combined with CT for diagnostics.…”

Section: Introductionmentioning

confidence: 99%

Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer

et al. 2017

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Abstract. Non-small cell lung cancer (NSCLC) is a major cause of morbidity and mortality, and patients with NSCLC are frequently diagnosed at an advanced stage. This is primarily due to a lack of advanced and sensitive protocols for the detection of early stage NSCLC. Therefore, methods for the accurate diagnosis of early stage NSCLC are urgently required to improve survival rates. The present study investigated the use of contrast-enhanced computerized tomography (CECT) combined with a targeted nanoparticle contrast agent (TNCA) to diagnose early-stage NSCLC in a mice xenograft model. The TNCA used was lenvatinib, a multi-target tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor 1-3, fibroblast growth factor receptor 1-4, platelet-derived growth factor receptor β, proto-oncogene tyrosine-protein kinase receptor Ret and mast/stem cell growth factor receptor Kit. Xenograft NSCLC mice were established and used to analyze the efficacy of CECT-TNCA compared with CT scanning alone. The TNCA was inhaled with the use of an atomizer. The results demonstrated that CECT-TNCA improved the sensitivity of the diagnosis of early stage NSCLC. In addition, imaging using the TNCA enabled the visualization of nodules in the lung in mice with early stage NSCLC. In addition, lung nodule signal enhancement was increased in CECT-TNCA compared with CT, suggesting a high accurate accumulation of the TNCA in tumor nodules. Mice diagnosed with early stage NSCLC exhibited a higher eradication rate of NSCLC after treatment with cisplatin compared with mice with advanced stage NSCLC. These data indicate that the sensitivity and accuracy of CT imaging for the diagnosis of early stage NSCLC was improved through combination with the liposome-encapsulated TNCA.

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Inorganic nanoparticle-based contrast agents for molecular imaging

Cited by 223 publications

References 125 publications

Applications of gold nanorods in biomedical imaging and related fields

Applications of gold nanorods in biomedical imaging and related fields

New generation of magnetic and luminescent nanoparticles for in vivo real-time imaging

Contrast‑enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early‑phase non‑small cell lung cancer

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