Inorganic arsenic methylation by rat tissue slices

Georis, B.; Cárdenas, A. de Pablo; Buchet, J. P.; Lauwerys, Robert

doi:10.1016/0300-483x(90)90070-w

Cited by 57 publications

(20 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of smoking may be related to competition between arsenic and some of the many chemicals found in cigarette smoke for common detoxification pathways or factors. For example, glutathione (GSH) is involved in several steps of InAs metabolism (25,26) and is likely to play a part in the detoxification of several polycyclic aromatic hydrocarbon epoxides generated from cigarette smoke (27). Experimental studies have shown an elevation in GSH in response to arsenic insult (28), and levels of GSH are higher in the bladder tissue of smokers compared to nonsmokers (29).…”

Section: Discussionmentioning

confidence: 99%

Methylation Study of a Population Environmentally Exposed to Arsenic in Drinking Water

Hopenhayn‐Rich¹,

Biggs²,

Smith³

et al. 1996

Environmental Health Perspectives

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Methylation Study of a Population Environmentally Exposed to Arsenic in Drinking Water

Hopenhayn‐Rich¹,

Biggs²,

Smith³

et al. 1996

Environmental Health Perspectives

View full text Add to dashboard Cite

“…This enhancement of arsenic-induced injury in GSH-depleted animals, may result from impaired methylation. Pretreatment with depletors of GSH levels in hamsters (12), rat (13), and rat tissue slices (6), impaired the methylation of inorganic arsenic. It has been shown that methylation renders arsenic less reactive with tissue and therefore facilitates its elimination from the body (14).…”

Section: Introductionmentioning

confidence: 96%

“…Studies in vivo and in vitro have concluded that GSH may play a role in arsenic detoxification through different mechanisms: facilitation of its uptake by the cells (6), modulation of the first methylation reaction (7), and stimulation of the excretion of dimethylarsinic acid (6). Furthermore, it has been shown that GSH participates in the biliary excretion of arsenic (8).…”

Section: Introductionmentioning

confidence: 99%

Arsenic Increased Lipid Peroxidation in Rat Tissues by a Mechanism Independent of Glutathione Levels

Ramos¹,

Carrizales²,

Yáñez³

et al. 1995

Environmental Health Perspectives

View full text Add to dashboard Cite

The role of lipid peroxidation in the mechanism of arsenic toxicity was investigated in female rats pretreated with N-acetylcysteine (NAC, a glutathione [GSHI inducer) or with buthionine sulfoximine (BSO, a GSH depletor). Rats were challenged with sodium arsenite, and sacrificed 1 hr after this treatment. Results showed that arsenic decreased GSH levels and increased lipid peroxidation in liver, kidney, and heart, with a larger effect at 18.2 mg/kg than at 14.8 mg/kg for lipid peroxidation induction. In the liver of rats treated with arsenic, pretreatment with NAC increased the levels of GSH and decreased lipid peroxidation. In kidney and heart, NAC pretreatment protected the tissues against arsenic-induced depletion of GSH levels,but the same degree of protection was not found for lipid peroxidation induction. In its turn, BSO had an additive effect with arsenic in lowering the levels of GSH in the liver and kidney, but an inverse correlation between GSH levels and lipid peroxidation was found only in liver. Arsenic content in tissues of rats pretreated with NAC was lower than in rats treated only with arsenic. In rats with depleted levels of GSH (BSO-pretreated rats), a shift in arsenic tissue distribution was found, with higher levels in skin and lower levels in kidney. A clear tendency for a positive correlation between arsenic concentration and lipid peroxidation levels was found in liver, kidney, and heart. -Environ Health Perspect 103(Suppl 1): 85-88 (1995)

show abstract

“…While 12 and 36 months is 500-600 ml/day, between the ages of 37 and 60 months is 600-700 ml/day, and between the ages of 61 and 96 months is 650-1,000 ml/day (24). The site-specific urinary arsenic study measured urine volume for a subset of 25 children at 240 ml/day for children under 36 months; 355 ml/day for children between 36 and 60 months; and 432 mI/day for children greater than 60 months of age.…”

Section: Discussionmentioning

confidence: 99%

“…The population of the town is approximately 12,000. Copper concentrating and smelting operations began in the area around 1884 and continued until 1980.…”

mentioning

confidence: 99%

Site-specific data confirm arsenic exposure predicted by the U.S. Environmental Protection Agency.

Walker¹,

Griffin²

1998

Environ Health Perspect

View full text Add to dashboard Cite

The EPA uses an exposure assessment model to estimate daily intake to chemicals of potential concern. At the Anaconda Superfund site-in Montana, the EPA exposure assessment model was used to predict total and speciated urinary arsenic concentrations. Predicted concentrations were then compared to concentrations measured in children living near the site. When site-specific information on concentrations of arsenic in soil, interior dust, and diet, site-specific ingestion rates, and arsenic absorption rates were used, measured and predicted urinary arsenic concentrations were in reasonable agreement. The central tendency exposure assessment model successfully described the measured urinary arsenic concentration for the majority of children at the site.The reasonable maximum exposure assessment model successfully identified the uppermost exposed population. While the agreement between measured and predicted urinary arsenic is good, it is not exact. The variables that were identified which influenced agreement included soil and dust sample collection methodology, daily urinary volume, soil ingestion rate, and the ability to define the exposure unit. The concentration of arsenic in food affected agreement between measured and predicted total urinary arsenic, but was not considered when comparing measured and predicted speciated urinary arsenic. Speciated urinary arsenic is the recommended biomarker for recent inorganic arsenic exposure. By using site-specific data in the exposure assessment model, predicted risks from exposure to arsenic were less than predicted risks would have been if the EPA's default values had been used in the exposure assessment model. This difference resulted in reduced magnitude and cost of remediation while still protecting human health. Key wordk: arsenic bioavailability, arsenic biomarkers, exposure assessment, soil and dust ingestion, urinary arsenic concentrations.

show abstract

Inorganic arsenic methylation by rat tissue slices

Cited by 57 publications

References 20 publications

Methylation Study of a Population Environmentally Exposed to Arsenic in Drinking Water

Methylation Study of a Population Environmentally Exposed to Arsenic in Drinking Water

Arsenic Increased Lipid Peroxidation in Rat Tissues by a Mechanism Independent of Glutathione Levels

Site-specific data confirm arsenic exposure predicted by the U.S. Environmental Protection Agency.

Contact Info

Product

Resources

About