Innovative synthesis of citrate-coated superparamagnetic Fe3O4 nanoparticles and its preliminary applications

Srivastava, Sarika; Awasthi, Rishi; Gajbhiye, N. S.; Agarwal, Vikas; Singh, Amit; Yadav, Abhishek; Gupta, Rakesh K.

doi:10.1016/j.jcis.2011.03.059

Cited by 81 publications

(26 citation statements)

References 44 publications

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“…At higher concentrations, cell viability decreased markedly. 48 Furthermore, after exposing endothelial cells to citric acid-coated iron oxide nanoparticles, dose-dependent effects on human umbilical vein endothelial cells' viability, cytoskeleton, and function were demonstrated. 49 On the other hand, cationic polymeric manganese ferrite nanoparticles exhibited higher cytotoxicity in macrophages (RAW 264.7 cells) and lower cellular membrane rigidity than anionic and nonionic polymeric manganese ferrite nanoparticles.…”

mentioning

confidence: 98%

The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5

López-Abarrategui¹,

Figueroa-Espí

Lugo-Alvarez³

et al. 2016

IJN

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Diseases caused by bacterial and fungal pathogens are among the major health problems in the world. Newer antimicrobial therapies based on novel molecules urgently need to be developed, and this includes the antimicrobial peptides. In spite of the potential of antimicrobial peptides, very few of them were able to be successfully developed into therapeutics. The major problems they present are molecule stability, toxicity in host cells, and production costs. A novel strategy to overcome these obstacles is conjugation to nanomaterial preparations. The antimicrobial activity of different types of nanoparticles has been previously demonstrated. Specifically, magnetic nanoparticles have been widely studied in biomedicine due to their physicochemical properties. The citric acid-modified manganese ferrite nanoparticles used in this study were characterized by high-resolution transmission electron microscopy, which confirmed the formation of nanocrystals of approximately 5 nm diameter. These nanoparticles were able to inhibit Candida albicans growth in vitro. The minimal inhibitory concentration was 250 µg/mL. However, the nanoparticles were not capable of inhibiting Gram-negative bacteria ( Escherichia coli ) or Gram-positive bacteria ( Staphylococcus aureus ). Finally, an antifungal peptide (Cm-p5) from the sea animal Cenchritis muricatus (Gastropoda: Littorinidae) was conjugated to the modified manganese ferrite nanoparticles. The antifungal activity of the conjugated nanoparticles was higher than their bulk counterparts, showing a minimal inhibitory concentration of 100 µg/mL. This conjugate proved to be nontoxic to a macrophage cell line at concentrations that showed antimicrobial activity.

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confidence: 98%

The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5

López-Abarrategui¹,

Figueroa-Espí

Lugo-Alvarez³

et al. 2016

IJN

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“…Magnetite NPs were prepared by chemical co-precipitation method under alkaline condition [18]. Molar ratio of Fe 2+ and Fe 3+ salts was maintained at 1:2.…”

Section: Synthesis Of Magnetite Npsmentioning

confidence: 99%

“…The obtained citrate-coated MNPs (CMNPs) were separated with external magnetic field. Citric acid was used as a coating agent for colloidal stabilization of MNPs in aqueous solution and to prevent aggregation of MNPs [18].…”

Section: Synthesis Of Citrate-coated Fe 3 O 4 Npsmentioning

confidence: 99%

Synthesis and heterogeneous catalytic activity of covalently immobilized hexamine cation as a magnetically-recoverable nanocatalyst

2015

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“…According to references (Chu et al 2011;Srivastava et al 2011), a modified method was used to synthesize the Fe 3 O 4 magnetic nanoparticles. 1.4884 g FeCl 3 Á 6H 2 O and 0.7651 g FeSO 4 Á 7H 2 O were dissolved in 110 mL doubly distilled water, and the solution was transferred to a 250-mL three-neck flask and stirred vigorously for 30 min.…”

Section: Synthesis Of Fe 3 O 4 Mnpsmentioning

confidence: 99%

Determination of Hydrogen Peroxide Using a Novel Sensor Based on Fe₃O₄Magnetic Nanoparticles

Dong

Lou

et al. 2014

Analytical Letters

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Fe 3 O 4 magnetic nanoparticles were synthesized by chemical co-precipitation with sodium citrate as a surfactant and were used with chitosan to construct a novel hydrogen peroxide sensor. The electrochemical behavior of hydrogen peroxide at the sensor was investigated by cyclic voltammetry. The composite film electrocatalyzed the reduction of hydrogen peroxide, and the peak current increased linearly with concentration from 1.00 Â 10 À5 to 1.00 Â 10 À3 mol Á L À1 (R ¼ 0.9974) with a detection limit of 1.53 Â 10 À6 mol Á L À1 . This novel nonenzyme sensor provided good sensitivity, stability, and precision with potential applications.

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Innovative synthesis of citrate-coated superparamagnetic Fe3O4 nanoparticles and its preliminary applications

Cited by 81 publications

References 44 publications

The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5

The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5

Synthesis and heterogeneous catalytic activity of covalently immobilized hexamine cation as a magnetically-recoverable nanocatalyst

Determination of Hydrogen Peroxide Using a Novel Sensor Based on Fe₃O₄Magnetic Nanoparticles

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Innovative synthesis of citrate-coated superparamagnetic Fe3O4 nanoparticles and its preliminary applications

Cited by 81 publications

References 44 publications

The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5

The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5

Synthesis and heterogeneous catalytic activity of covalently immobilized hexamine cation as a magnetically-recoverable nanocatalyst

Determination of Hydrogen Peroxide Using a Novel Sensor Based on Fe3O4Magnetic Nanoparticles

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Determination of Hydrogen Peroxide Using a Novel Sensor Based on Fe₃O₄Magnetic Nanoparticles