Innovative Scientific Research: Theory and Practice

,; Vladlenov, Denis

doi:10.46299/isg.p.2023.2.10

Proceedings of the X International Scientific and Practical Conference 2023

DOI: 10.46299/isg.p.2023.2.10

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Innovative Scientific Research: Theory and Practice

Denis Vladlenov

Abstract: студентка 1 курсу «Магістр» Сумський національний аграрний університет В умовах війни фермера та сільське господарство зіткнулись з багаточисленними викликами і проблемами. Обстріли, відключення електроенергії, забезпечення безпеки та захисту тварин, економічні труднощі, а виробництво продуктів та кормів взагалі було під ризиком повного припинення.Якщо порівняти наявність поголів'я за останні три роки, то ми спостерігаємо

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2024

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Assessment of bioequivalence of veterinary drugs “Hollicalm” and “Serenia” in the form of tablets in the body of dogs

Abramov,

Balyshev,

Golovin

et al. 2024

Agrarnaâ nauka

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This paper describes the results of a study of the bioequivalence of the generic drug “Hollicalm” in comparison with the reference drug “Sereniya”. The experiment was carried out on 6 dogs. For this experiment, a sequential bioequivalence study design was used. The period between the administration of reference and generic drugs to animals was 72 hours. The drugs were administered to dogs once, individually, orally. The study drugs contained 60 mg of maropitant per tablet. The dose of the active substance that was administered to each animal was 8 mg of maropitant per 1 kg of animal weight. Blood samples were taken from dogs before drug administration, then at 14 time points within 48 hours to subsequently obtain blood serum. The content of maropitant was determined in the samples of blood serum using high-performance liquid chromatography coupled with mass-spectrometry detection. The obtained concentrations of the active substance served as the basis for calculating its pharmacokinetic parameters in dogs. The statistical analysis showed that two-sided confidence intervals for the Cmax and AUC0-t ratios were in the range of 80–125%. The results of the study allowed us to draw a conclusion about the bioequivalence of the drugs “Hollicalm” and “Sereniya”.

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Assessment of bioequivalence of veterinary drugs “Hollicalm” and “Serenia” in the form of tablets in the body of dogs

Abramov,

Balyshev,

Golovin

et al. 2024

Agrarnaâ nauka

View full text Add to dashboard Cite

show abstract

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Innovative Scientific Research: Theory and Practice

Cited by 1 publication

References 5 publications

Assessment of bioequivalence of veterinary drugs “Hollicalm” and “Serenia” in the form of tablets in the body of dogs

Assessment of bioequivalence of veterinary drugs “Hollicalm” and “Serenia” in the form of tablets in the body of dogs

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