Innovative phytoformulation containing capsaicinoids: Microparticles development, analytical method validation, and anti-ulcer effect

Curcumin (CUR) shows potential use for treating cancer. However, CUR has low solubility and reduced bioavailability, which limit its clinical effect. Therefore, the development of nanocarriers can overcome these problems and can ensure the desired pharmacological effect. In addition, it is mandatory to prove the quality, the efficacy, and the safety for a novel nanomedicine to be approved. In that sense, this paper aimed (a) to prepare CUR-loaded polyethylene glycol-poly(ε-caprolactone) nanocapsules; (b) to validate an analytical method by high performance liquid chromatography (HPLC) for quantifying CUR in these nanoformulations; (c) to evaluate the physicochemical stability of these formulations; and to investigate their cytotoxicity on NIH-3T3 mouse fibroblast cells. The HPLC method was specific to CUR in the loaded nanocapsules, linear (r = 0.9994) in a range of 10.0 to 90.0 µg.mL-1 with limits of detection and quantification of 0.160 and 0.480 µg.mL-1 , respectively. Precision was demonstrated by a relative standard deviation lower than 5%. Suitable accuracy (102.37 ± 0.92%) was obtained. Values of pH, particle size, polydispersity index, and zeta potential presented no statistical difference (p > 0.05) for CUR-loaded nanoparticles. No cytotoxicity HIGHLIGHTS  A simple and low-cost HPLC method for determining curcumin in nanocapsules was validated.  PEG-PCL nanocapsules containing curcumin showed suitable stability over 60 days.  No cytotoxicity was observed against NIH-3T3 mouse embryo fibroblast cell line.  PEG-PCL nanocapsules containing curcumin can be further investigated for cancer treatment. 2 Rudnik, L.A.C.; et al.

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Modification of Light Characteristics Affect the Phytochemical Profile of Peppers

Jiménez-Viveros

Núñez-Palenius

Fierros-Romero

et al. 2023

Horticulturae

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Capsicum is one of the most economically important genera in the Solanaceae family. Capsicum fruits (peppers) are rich in phytochemicals with high nutritional value and significant health-promoting characteristics. The phytochemical profile of peppers consists of capsaicinoids, carotenoids, and phenolics, primarily. Currently, most of the pepper production is carried out under protected horticulture conditions. The objective of this article was to provide a comprehensive review on how light characteristics and manipulation by different horticultural technologies can affect the biosynthesis and accumulation of phytochemicals in Capsicum fruits. The use of shade nets or plastic covers to reduce light intensity does not seem to yield consistent responses on the phytochemical profile, as the final profile results from the interaction of several factors. Other factors involved in the accumulation of phytochemicals include temperature, water availability and plant nutrition. Exposure of plants to supplemental light with specific wavelengths (using LEDs) seems to result in a more precise stimulation of specific metabolites. In this article, we examine the effects of light irradiance and spectrum on the specific phytochemicals of Capsicum fruits.

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Innovative phytoformulation containing capsaicinoids: Microparticles development, analytical method validation, and anti-ulcer effect

Cited by 3 publications

References 3 publications

Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment

Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment

PEG-PCL Nanocapsules Containing Curcumin: Validation of HPLC Method for Analyzing Drug-loading Efficiency, Stability Testing and Cytotoxicity on NIH-3T3 Cell Line

Modification of Light Characteristics Affect the Phytochemical Profile of Peppers

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