Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications

Pourmadadi, Mehrab; Eshaghi, Mohammad Mahdi; Ostovar, Shima; Mohammadi, Zahra Ali; Sharma, Rakesh; Paiva‐Santos, Ana Cláudia; Rahmani, Elham; Rahdar, Abbas; Pandey, Sadanand

doi:10.1016/j.jddst.2023.104357

Cited by 23 publications

(7 citation statements)

References 385 publications

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“…The drug molecules are evenly distributed throughout the polymer matrix or adsorbed on the surface, resulting in a regulated release pattern [ 180 ]. The general method of preparation involves the solubilization of monomers and drugs in a suitable solvent, followed by the induction of cross-linking of monomers, thus entrapping the drug molecules inside the matrix [ 25 ]. These NPs allow surface modification to improve their drug-targeting efficiency.…”

Section: Classification Of Nanomaterialsmentioning

confidence: 99%

“…Based on drug delivery applications, nanomaterials (NMs) are mainly classified into two categories: (i) inorganic NMs such as silver, platinum, gold, iron, copper etc, (metallic NMs), graphene and its derivatives (carbon-based NMs), (ii) organic NMs including the NPs derived from polymer (polymeric nanocapsules, nanospheres, dendrimers, nanogel, etc) and lipids (liposomes, niosomes, micelles, solid lipid nanoparticles (SLN), etc. ) [ 25 , 26 ]. These NPs can carry and deliver therapeutic molecules such as chemotherapeutic agents, radiotherapeutics, photosensitizers, photothermal agents, monoclonal antibodies (mAb), peptides and proteins to the target site.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Parhi,

Kaishap,

Jena

2023

ADMET DMPK

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Background and Purpose: Safe and effective drug delivery is crucial for the treatment of cancer, which is quite impossible to achieve through traditional methods. Among all types of cancer, skin melanoma is known for its aggressive metastasizing ability and an unprecedented higher degree of lethalness, limiting the overall therapeutic efficacy. Here, we focus on the different types of nanomaterials (NMs) and their drug delivery applications against melanoma. Experimental Approach: All relevant publications, including research papers, reviews, chapters and patents, were assessed using search engines such as Scopus and PubMed, up to the end of August of 2023. The keywords used in the search were: nanomaterials, melanoma, drug delivery routes for melanoma, and nanomaterial-based drug delivery systems (DDS). Most of the publications out of 234 cited in this review are from the last five years. Key Results: The recent advancement and mechanism of action of various NMs against melanoma, including inorganic metallic and carbon-based NMs, organic polymeric and lipid-based NMs, and cell-derived vesicles are discussed. We also focus on the application of different NMs in the delivery of therapeutic agents for melanoma therapy. In addition, the skin and melanoma, genetic mutation and pathways for melanoma, conventional treatment options, and delivery routes for therapeutic agents are also discussed briefly. Conclusion: There are few NM-based DDS developed in the lab set up recently. The findings of this review will pave the path for the development of NM-based DDS on an industrial scale and help in the better management of skin melanoma.

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Section: Classification Of Nanomaterialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Parhi,

Kaishap,

Jena

2023

ADMET DMPK

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“…In recent decades, there has been increased interest in developing innovative methods to deliver drugs. In this review, we will discuss the pros and cons of drug delivery systems, the basic as well as physicochemical characteristics that could render a drug suitable for pharmaceutical formulation, and the techniques used to assess delivery sustainability, toxicity at the site of delivery, and its feasibility [ 1 ]. Despite the abundance of research on various methods for administering drugs, oral administration is still the most efficient, least complicated, and safest [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan in Oral Drug Delivery Formulations: A Review

Sangnim,

Dheer,

Jangra

et al. 2023

Pharmaceutics

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Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common delivery method, although it is not always the most effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One of the most significant barriers that medications must overcome to exert a therapeutic effect is the impact of the first hepatic transit. Studies have shown that controlled-release systems using nanoparticles composed of biodegradable natural polymers significantly improve oral administration, which is why these materials have attracted significant attention. Chitosan possesses a wide variety of properties and functions in the pharmaceutical as well as healthcare industries. Drug encapsulation and transport within the body are two of its most important features. Moreover, chitosan can enhance drug efficacy by facilitating drug interaction with target cells. Based on its physicochemical properties, chitosan can potentially be synthesized into nanoparticles, and this review summarizes recent advances and applications of orally delivered chitosan nanoparticle interventions.

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“…Chinese furniture technology is diverse, as different regions prefer different production techniques based on their strengths. For example, Beijing-style furniture is known for its high production level and luxurious decoration, as skilled craftsmen from all over the country gather in the palace office of the capital to produce furniture for the palace [8].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Implementation of Multimedia Technology in Contemporary Home Product Design for Regional Culture Inheritance and Innovation

Sheng

2023

Int. J. Appl. Inf. Manag.

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In recent years, the design market in China for household products has seen a surge in scale and speed. This shift has taken place from a decoration market to a design market. There is now a wide range of styles available for modern home product designs, with Western design styles becoming increasingly popular. However, it has been noticed that some domestic designers have followed the principles of modernism, minimalism, and high-techism, and this has resulted in many designs being created by simple copying of computer-generated designs, without much thought. This approach has led to the loss of the individuality of modern home product design styles. A modern household product design with an elegant taste and extraordinary style is not solely dependent on how much money is spent and how many high-grade decorative materials are used. It is important to combine regional culture with the appropriate use of the elements of modern household product design. It is also essential to create a fully functional, beautiful, generous, and elegant style for indoor environments with limited room space. Regional modern household product design refers to the combination of the local natural environment and cultural environment. It emphasizes local characteristics and national style, and the nationalization of modern household product design and creation tendency. In the design process, local materials and practices should be used as much as possible to display the characteristics of local conditions and merge the overall style with the local environment. To achieve this goal, it is essential to consider the region fully. Regional modern household product design can create a unique and individual design style. The use of local materials and practices will enable the design to reflect the characteristics of the local environment, resulting in a cohesive style. The use of regional culture and local elements will make the design more attractive to potential customers. Therefore, it is necessary to focus on creating a unique style of modern household product design, which combines regional culture with modern design elements.

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Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications

Cited by 23 publications

References 385 publications

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Chitosan in Oral Drug Delivery Formulations: A Review

Exploring the Implementation of Multimedia Technology in Contemporary Home Product Design for Regional Culture Inheritance and Innovation

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