Innovative Interventional and Imaging Registries: Precision Medicine in Cerebrovascular Disorders

Abstract

Background: Precision medicine in cerebrovascular disorders may be greatly advanced by the use of innovative interventional and imaging-intensive registries. Registries have remained subsidiary to randomized controlled trials, yet vast opportunities exist to leverage big data in stroke. Summary: This overview builds upon the rationale for innovative, imaging-intensive interventional registries as a pivotal step in realizing precision medicine for several cerebrovascular disorders. Such enhanced registries may serve as a model for expansion of our translational research pipeline to fully leverage the role of phase IV investigations. The scope and role of registries in precision medicine are considered, followed by a review on the history of stroke and interventional registries, data considerations, critiques or barriers to such initiatives, and the potential modernization of registry methods into efficient, searchable, imaging-intensive resources that simultaneously offer clinical, research and educational added value. Key Messages: Recent advances in technology, informatics and endovascular stroke therapies converge to provide an exceptional opportunity for registries to catapult further progress. There is now a tremendous opportunity to deploy registries in acute stroke, intracranial atherosclerotic disease and carotid disease where other clinical trials leave questions unanswered. Unlike prior registries, imaging-intensive and modernized methods may leverage current technological capabilities around the world to efficiently address key objectives and provide added clinical, research and educational value.

Disease registry system in northwest of Iran: The first step forward in research progress with review of literature

“…Information of these centers has been published in 12 Information Sciences Institute (ISI) papers in the last two years, indicating a significant development for northwest of Iran universities. Observational studies and randomized controlled trials (RCTs) with focus on specific therapeutic interventions are the basis of evidence-based medicine, 5 but the registry Accepted Pending Need to correct Complet Rejected system data can be effective in both fields: patient-specific factors and a broad range of treatment variables. 5 The RCT studies suffer from various limitations.…”

“…Observational studies and randomized controlled trials (RCTs) with focus on specific therapeutic interventions are the basis of evidence-based medicine, 5 but the registry Accepted Pending Need to correct Complet Rejected system data can be effective in both fields: patient-specific factors and a broad range of treatment variables. 5 The RCT studies suffer from various limitations. With the development of societies and expansion of the population, we are faced with a dramatic increase in chronic and traumatic diseases.…”

“…1 Today, registry systems regarding cardiovascular, chronic kidney, metabolic, trauma, and neurological diseases are established in public health care of many countries. 5 Iran has the most recent cancer registration system in which the data are collected and used in research programs. 3,4 Also, the burn registry system is a developed program in Iran (with the cooperation of Iran Burn Research Center) which is intended to collect exact and accurate data from all over the country.…”

Application of holistic nursing in care for cranial neurointervention

“…Recently, cerebrovascular diseases have some features, such as high recurrence rate, high incidence rate and many complications [1,2]. In dept.…”

Crowdsourcing Precision Cerebrovascular Health: Imaging and Cloud Seeding A Million Brains Initiative™

“…Research on cerebrovascular health overwhelmingly emphasizes control of data diversity, rather than consideration of the complex relationships between numerous variables. In our attempts to determine what health-care strategy is right for a particular individual at a specific moment, we exclude the majority of susceptible individuals from the study population, focus only on dramatic or significant changes in disease magnitude, and often fail to account for many other causes that impact long-term health outcomes (2). Crowdsourcing, an unorthodox approach to modern data collection in medicine, creates an unusual paradigm to study precision cerebrovascular health, eliminating the relative isolation and non-standardized nature of current imaging data infrastructure, while shifting emphasis to the astounding capacity of big data in the cloud.…”