Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis

Strategies for enhanced gene delivery to the central nervous system

“… 47 These nano-sized lipid carriers show significant potential for efficiently transporting therapeutic agents to the CNS. 48 Key advancements in the utilization of lipid nanoparticles for CNS applications include: enhanced BBB permeability: LNPs have been intricately engineered to augment the delivery of drugs across the BBB in small animals. 6 Modifications in LNP composition and surface characteristics facilitate their passage through the BBB, predominantly through receptor-mediated transport.…”