Innovative Digital Tools and Surveillance Systems for the Timely Detection of Adverse Events at the Point of Care: A Proof-of-Concept Study

Hoppe, Christian; Obermeier, Patrick; Muehlhans, Susann; Alchikh, Maren; Seeber, Lea; Tief, Franziska; Karsch, Katharina; Chen, Xi; Boettcher, Sindy; Diedrich, Sabine; Conrad, Tim; Kisler, Bron; Rath, Barbara

doi:10.1007/s40264-016-0437-6

Cited by 9 publications

(12 citation statements)

References 60 publications

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“…Children are the most avid transmitters of respiratory viral infections, and the information gained from syndromic surveillance in children's hospitals can complement decentralized sentinel surveillance systems in a meaningful way [133]. With the advent of rapid diagnostics and mobile health applications, it has now become possible to monitor virological and clinical end points in real time [134][135][136][137][138][139][140].…”

Section: Discussionmentioning

confidence: 99%

Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials

Rath

Conrad

Myles

et al. 2017

Expert Review of Anti-infective Therapy

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Influenza-Like Illness is a leading cause of hospitalization in children. Disease burden due to influenza and other respiratory viral infections is reported on a population level, but clinical scores measuring individual changes in disease severity are urgently needed. Areas covered: We present a composite clinical score allowing individual patient data analyses of disease severity based on systematic literature review and WHO-criteria for uncomplicated and complicated disease. The 22-item ViVI Disease Severity Score showed a normal distribution in a pediatric cohort of 6073 children aged 0-18 years (mean age 3.13; S.D. 3.89; range: 0 to 18.79). Expert commentary: The ViVI Score was correlated with risk of antibiotic use as well as need for hospitalization and intensive care. The ViVI Score was used to track children with influenza, respiratory syncytial virus, human metapneumovirus, human rhinovirus, and adenovirus infections and is fully compliant with regulatory data standards. The ViVI Disease Severity Score mobile application allows physicians to measure disease severity at the point-of care thereby taking clinical trials to the next level.

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Section: Discussionmentioning

confidence: 99%

Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials

Rath

Conrad

Myles

et al. 2017

Expert Review of Anti-infective Therapy

Self Cite

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“…Advances in information technologies permits to collect PROMs by means of electronic tools, namely electronic PRO (ePRO). The development of such tools allowing the integration of PROMs with patient-related data from hospital and laboratory sources warrants a follow-up at several levels, also at distance, with data that can be automatically transferred in real time to a computer server [99][100][101][102]. Moreover, all clinically relevant actions based on PRO scores can be added to the patient's electronic medical record, thus allowing the health-care providers to be always aware of patient conditions and to move smoothly from an active treatment to palliation.…”

Section: The Integrated Modelmentioning

confidence: 99%

“…Novel tools allowing routine assessment of PROs via smartphone and tablet applications have proven user friendly to patients, with a low loss of data and with the possibility to monitor patient compliance to pharmacotherapy [102,103].…”

Section: The Integrated Modelmentioning

confidence: 99%

Venous Thromboembolism in Cancer Patients on Simultaneous and Palliative Care

Riondino

Ferroni

Monte

et al. 2020

Cancers

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Simultaneous care represents the ideal integration between early supportive and palliative care in cancer patients under active antineoplastic treatment. Cancer patients require a composite clinical, social and psychological management that can be effective only if care continuity from hospital to home is guaranteed and if such a care takes place early in the course of the disease, combining standard oncology care and palliative care. In these settings, venous thromboembolism (VTE) represents a difficult medical challenge, for the requirement of acute treatments and for the strong impact on anticancer therapies that might be delayed or, even, totally discontinued. Moreover, cancer patients not only display high rates of VTE occurrence/recurrence but are also more prone to bleeding and this forces clinicians to optimize treatment strategies, balancing between hemorrhages and thrombus formation. VTE prevention is, therefore, regarded as a double-edged sword. Indeed, while on one hand the appropriate use of antithrombotic agents can reduce VTE occurrence, on the other it significantly increases the bleeding risk, especially in the frail patients who present with multiple co-morbidities and poly-therapy that can interact with anticoagulant drugs. For these reasons, thromboprophylaxis should start while active cancer treatment is ongoing, according to a simultaneous care model in a patient-centered perspective.

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“…Solution : We developed the ViVI Automated Case Classification Tool (VACC-Tool™), a mobile application allowing doctors to assess the patient's status at the point of care – thereby comparing the disease presentation to multiple case definitions at the same time. 2 Most immunizations are performed during early childhood. This is why the VACC-Tool™ was specifically designed to perform across the pediatric and adult age spectrum.…”

mentioning

confidence: 99%

“…We developed the ViVI Automated Case Classification Tool (VACC-Tool™), a mobile application allowing doctors to assess the patient's status at the point of care – thereby comparing the disease presentation to multiple case definitions at the same time. 2 …”

mentioning

confidence: 99%