Innovative design of bone quality-targeted intervertebral spacer: accelerated functional fusion guiding oriented collagen and apatite microstructure without autologous bone graft

Matsugaki, Aira; Ito, Manabu; Kobayashi, Yoshiya; Matsuzaka, Tadaaki; Ozasa, Ryosuke; Ishimoto, Takuya; Takahashi, Hiroyuki; Watanabe, Ryota; Inoue, Takayuki; Yokota, Katsuhiko; Nakashima, Yoshio; Kaito, Takashi; Okada, Seiji; Hanawa, Takao; Matsuyama, Yukihiro; Matsumoto, Morio; Taneichi, Hiroshi; Nakano, Takayoshi

doi:10.1016/j.spinee.2022.12.011

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…Generally, the radially oriented pores can facilitate cell ingrowth, longitudinal alignment of cells, and integration with the surrounding tissue, and may be suitable for in vivo applications [41]. Similar findings were also discussed in the research of Matsugaki [42] and Ishimoto [43]. They designed a honeycomb tree structure with through-pores and a grooved substrate for the spinal cages.…”

Section: The Effect Of Porous Geometry On the In Vivo Performancesmentioning

confidence: 55%

“…It was found in their research that such a through-pore honeycomb tree structure provided a direct scaffold that guided the bone matrix in its collagen and apatite orientation. Besides, such a design also exhibited greater strength at the bone interface compared with that of conventional and gold-standard box-type designs with autologous iliac bone grafts [42,43]. These Based on the above cognition and the pore morphology features, the better in vivo performance of Voronoi structures could be attributed to the following reasons:…”

Section: The Effect Of Porous Geometry On the In Vivo Performancesmentioning

confidence: 91%

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Mechanical Properties and in Vivo Assessment of Electron Beam Melted Porous Structures for Orthopedic Applications

Wang

Liu

et al. 2023

Metals

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Electron beam melting (EBM) is an additive manufacturing technique with the ability to produce porous implants with desired properties for orthopedic applications. This paper systematically investigated the mechanical properties and in vivo performance of two commonly used stochastic porous structures (the Voronoi structure and the randomized structure) fabricated by the EBM process. The pore geometries of two porous structures were characterized through micro-computed tomography (μCT). In addition, clinically relevant mechanical performances were evaluated for both structures, including tensile testing, shear testing and abrasion resistance testing. In vivo assessment of the two porous structures was further conducted in a dog model for three different follow-up periods. It was found that the Voronoi structures showed a higher mechanical strength compared to the randomized structures, even though both structures exhibited similar pore geometries. Further analysis revealed that the non-uniform stress distribution caused by the sample size and boundary effects led to a decrease in strength in the randomized structures. The in vivo assessments revealed the Voronoi structure exhibited a higher bone ingrowth ratio compared to the randomized structure due to its radially oriented pore geometry and homogenous pore size distribution. This study suggested that the EBM Ti-6Al-4V Voronoi porous structure has favorable mechanical performance and good osseointegration properties for orthopedic implants.

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Section: The Effect Of Porous Geometry On the In Vivo Performancesmentioning

confidence: 55%

Section: The Effect Of Porous Geometry On the In Vivo Performancesmentioning

confidence: 91%

Mechanical Properties and in Vivo Assessment of Electron Beam Melted Porous Structures for Orthopedic Applications

Wang

Liu

et al. 2023

Metals

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show abstract

Biomanufacturing in Japan: frontier research from 2018 to 2023

Cao,

Zhang,

Deng

et al. 2023

Bio-des. Manuf.

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The bone morphogenetic protein 2 analogue L51P enhances spinal fusion in combination with BMP2 in an in vivo rat tail model

Gantenbein,

Oswald,

Erbach

et al. 2024

Acta Biomaterialia

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Innovative design of bone quality-targeted intervertebral spacer: accelerated functional fusion guiding oriented collagen and apatite microstructure without autologous bone graft

Cited by 6 publications

References 36 publications

Mechanical Properties and in Vivo Assessment of Electron Beam Melted Porous Structures for Orthopedic Applications

Mechanical Properties and in Vivo Assessment of Electron Beam Melted Porous Structures for Orthopedic Applications

Biomanufacturing in Japan: frontier research from 2018 to 2023

The bone morphogenetic protein 2 analogue L51P enhances spinal fusion in combination with BMP2 in an in vivo rat tail model

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