Innovative Dental Stem Cell-Based Research Approaches: The Future of Dentistry

Abstract

Over the past decade, the dental field has benefited from recent findings in stem cell biology and tissue engineering that led to the elaboration of novel ideas and concepts for the regeneration of dental tissues or entire new teeth. In particular, stem cell-based regenerative approaches are extremely promising since they aim at the full restoration of lost or damaged tissues, ensuring thus their functionality. These therapeutic approaches are already applied with success in clinics for the regeneration of other organs and consist of manipulation of stem cells and their administration to patients. Stem cells have the potential to self-renew and to give rise to a variety of cell types that ensure tissue repair and regeneration throughout life. During the last decades, several adult stem cell populations have been isolated from dental and periodontal tissues, characterized, and tested for their potential applications in regenerative dentistry. Here we briefly present the various stem cell-based treatment approaches and strategies that could be translated in dental practice and revolutionize dentistry.

Bone alkaline phosphatase and osteocalcin expression of rat's Gingival mesenchymal stem cells cultured in platelet-rich fibrin for bone remodeling (in vitro study)

“…The osteogenic ability of GMSCs needs to be explored for further application and therapy. [ 2 9 7 10 ]…”

Needs assessment and research priorities in the oral and dental health with health promotion approach in Iran

“…[ 49 ] In this dimension, one of the high priority topics was “Study of the use of stem cells in the root canal therapies,” which was similar to the results of the Miran et al ’ study. [ 50 ]…”

Pulpo-Periodontal Regeneration: Management of Partial Failure Revascularization

“…The pulp capping and the regenerative procedure are used clinically, the other procedures must be verified and their interest confirmed regarding the existing techniques before including them in our therapeutic arsenal [ 16 – 18 ].…”