This article emphasizes the role of projects and project management in mastering global strategic crises to create a new multi-project environment, comprised of projects, programs, and project portfolios. Multi-projectivity has come to characterize modern society and requires an adjustment of organizational solutions, individual competencies of different systems, and changes in understanding the effects of a project. The current global strategic crises are identified; some call for urgent, systemic and global solutions involving the implementation of projects with the awareness that the necessary and project--influenced resources are limited. The article examines the knowledge society in the context of global strategic crises and expands previous interpretations of project-oriented society, stressing its role in overcoming global strategic crises. By expanding and integrating the knowledge society and the project-oriented society, the a uthors propose the establishment of a holistic project-knowledge society that sets the framework for overcoming global strategic crises, thereby ensuring the long--term survival of humankind. The article concludes with a diagram of the process of overcoming global strategic crises through a holistic project-knowledge society.