Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer

Paolino, Donatella; Cosco, Donato; Muzzalupo, Rita; Trapasso, Elena; Picci, Nevio; Fresta, Massimo

doi:10.1016/j.ijpharm.2007.11.037

Cited by 178 publications

(83 citation statements)

References 36 publications

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“…As PC held constant Maximum EE was obtained at PG ( It was noted from regression equation (Table 3), contour plots and 3D-respnse surface that EE had a positive relationship with PC and negative relationship with PG and ethanol. These results were in agreement with the reported results [14,16,20,31,32]. The drug is supposed to be entrapped in the aqueous compartment of the vesicles, and the decrease in the EE may be attributed to the increase in the fluidity of vesicles upon increase in the ethanol content leading to drug leakage [33].…”

Section: Preparation and Study Of The Effect Of Formulation Variablessupporting

confidence: 92%

Preparation and Optimization of Buccal Propranolol Hydrochloride Nanoethosomal Gel: A Novel Approach for Enhancement of Bioavailability

Sf¹,

Rm²,

Khames³

2017

J Nanomed Nanotechnol

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Section: Preparation and Study Of The Effect Of Formulation Variablessupporting

confidence: 92%

Preparation and Optimization of Buccal Propranolol Hydrochloride Nanoethosomal Gel: A Novel Approach for Enhancement of Bioavailability

Sf¹,

Rm²,

Khames³

2017

J Nanomed Nanotechnol

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“…Studies have shown that intravenous administration of methotrexate encapsulated in niosomes to S-180 tumor-bearing mice resulted in a total regression of tumor, slower drug clearance, and a higher plasma level of methotrexate [58]. Enhanced drug penetration was noted when 5-fluorouracil was formulated in bola-surfactant niosomes to treat skin cancer [59]. Despite enhanced antitumor activity, in some instances, encapsulation of the drug in niosomal vesicles reduces the toxicity in normal cells, as demonstrated in a study of preparation of niosome containing vincristine.…”

Section: Neoplasiamentioning

confidence: 99%

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

et al. 2017

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Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes' structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

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“…From the pharmaceutical viewpoint, the most important parameter to the colloidal drug delivery system is the encapsulation efficiency (Polino et al, 2008), which may be affected by three main areas, namely, the composition of PEGylated niosomes, the nature of drugs and the measurement method. For this reason, in this study, we investigated the different classes of non-ionic surfactants meanwhile keeping the other factors invariable and the corresponding order follows the order Span604Span404Span20 (Table 2).…”

Section: Encapsulation Efficiency Of the P-gna-nisvsmentioning

confidence: 99%

PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid

et al. 2013

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Gambogenic acid (GNA), a popular Chinese traditional medicine, has its limitations of coming into use due to its low aqueous solubility and poor bioavailability. In this study, therefore, the PEGylated non-ionic surfactant vesicles drug delivery systems were prepared from biocompatible non-ionic surfactant of Span60, cholesterol and dicetyl phosphate (DCP) by the improved ethanol injection method, and were modified with a polyethylene glycol monostearate15 (PEG15-SA). PEG15-SA, as a biocompatible, non-toxic and non-immunogenic hydrophilic segment, was grafted onto the surface of colloidal niosomes carries to reduce the uptake by the reticuloendothelial system (RES), prolonging the circulation time and attaining higher entrapment efficiency. To our knowledge, this work is the first to report that PEG15-SA was applied to coating of niosomes for encapsulation of GNA. The optimized PEG-GNA-NISVs (P-GNA-NISVs) were characterized in terms of mean vesicles size, polydispersity index (PDI), Zeta potential and entrapment efficiency of the P-GNA-NISVs. The results showed that the mean diameter, PDI, Zeta potential, and the entrapment efficiency of the P-GNA-NISVs were 70.1 nm, 0.166, À44.3 mV and 87.74%, respectively. Furthermore, the release studies of GNA from PEGylated niosomes in vitro and the pharmacokinetics in vivo exhibited a prolonged release profile as studied over 24 h. In conclusion, the result suggests that P-GNA-NISVs prepared in this way not only have higher encapsulation capacity, more colloidal stability but also offer an approach that the PEGylated niosomes is a promising carrier for anticancer GNA.

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Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer

Cited by 178 publications

References 36 publications

Preparation and Optimization of Buccal Propranolol Hydrochloride Nanoethosomal Gel: A Novel Approach for Enhancement of Bioavailability

Preparation and Optimization of Buccal Propranolol Hydrochloride Nanoethosomal Gel: A Novel Approach for Enhancement of Bioavailability

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid

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