Innovative approaches for the control of ticks and tick-borne diseases

Fuente, José de la; Mazuecos, Lorena; Contreras, Marinela

doi:10.1016/j.ttbdis.2023.102227

Cited by 9 publications

(3 citation statements)

References 59 publications

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“…Oral vaccine delivery platforms are also key to target wildlife species, but these are mainly based for subunit-based vaccines ( 32 ); whether mRNA-based vaccines could be used for such purpose remains to be explored in the future. Additionally, combining these vaccines with innovative approaches like quantum vaccinomics and para-transgenesis target multiple tick vector species and pathogen genetic variants ( 33 ).…”

Section: Integrative Strategies In Controlling Tick-borne Diseases: A...mentioning

confidence: 99%

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

González-Cueto,

de la Fuente,

López-Camacho

2024

Front. Immunol.

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The One Health approach, which integrates the health of humans, animals, plants, and ecosystems at various levels, is crucial for addressing interconnected health threats. This is complemented by the advent of mRNA vaccines, which have revolutionized disease prevention. They offer broad-spectrum effectiveness and can be rapidly customized to target specific pathogens. Their utility extends beyond human medicine, showing potential in veterinary practices to control diseases and reduce the risk of zoonotic transmissions. This review place mRNA vaccines and One Health in the context of tick-borne diseases. The potential of these vaccines to confer cross-species immunity is significant, potentially disrupting zoonotic disease transmission cycles and protecting the health of both humans and animals, while reducing tick populations, infestations and circulation of pathogens. The development and application of mRNA vaccines for tick and tick-borne pathogens represent a comprehensive strategy in global health, fostering a healthier ecosystem for all species in our interconnected world.

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Section: Integrative Strategies In Controlling Tick-borne Diseases: A...mentioning

confidence: 99%

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

González-Cueto,

de la Fuente,

López-Camacho

2024

Front. Immunol.

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“…10 The genetically engineered vaccine against the Rhipicephalus microplus Bm86, developed with the gut antigen molecule Bm86, was highly successful and became the first commercially available anti-tick vaccine, 11 and the midgut-functional molecules of the tiny tick, Bm91 and Bm95, were field tested, with a vaccine against the Bm95 antigen also being successfully developed for the control of Rhipicephalus microplus infections. 12 Subsequently, protein and nucleic acid vaccines have been progressively investigated, with the main targets of anti-tick protein vaccines being molecules derived from the tick's salivary glands or components of physiologically important pathways in its midgut or ovary. In particular, a class of functional molecules that contribute to the growth and development of ticks and their defense against the adverse external environment, for example, during blood feeding, ticks transmit pathogens without harming themselves, which is closely linked to defense function molecules.…”

Section: Introductionmentioning

confidence: 99%

The evaluation of cystatin protein vaccines based on the stress response of ticks triggered by low‐temperature and toxin stress in Haemaphysalis doenitzi

Zhang,

Gao,

Wang

et al. 2024

Pest Management Science

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BACKGROUNDTicks, which are obligate blood‐feeding parasites, transmit a wide range of pathogens during their hematophagic process. Certain enzymes and macromolecules play a crucial role in inhibiting several tick physiological processes, including digestion and reproduction. In the present study, genes encoding type 2 cystatin were cloned from the tick Haemaphysalis doenitzi and characterized, and the potential role of cystatin in tick control was assessed.RESULTSTwo cystatin genes, HDcyst‐1 and HDcyst‐2, whose open reading frames are 390 and 426 bp, respectively, were successfully cloned from H. doenitzi. Among the midgut, salivary glands, Malpighian tubules, and ovaries of ticks, the relative expression of HDcyst‐1 and HDcyst‐2 was highest in the midgut and salivary glands, respectively. Lipopolysaccharide injection and low‐temperature stress elevated cystatin expression in ticks. Both recombinant cystatin protein rHDcyst‐1 and rHDcyst‐2 vaccines increased antibody levels and significantly reduced tick engorgement and egg mass weights in immunized rabbits infested with H. doenitzi. Particularly, rHDcyst‐1 significantly prolonged tick engorgement time by 1 day and reduced egg‐hatching rates by 16.9%. Collectively, rHDcyst‐1 and rHDcyst‐2 protein vaccinations provided 64.1 and 51.8% protection to adult female ticks, respectively.CONCLUSIONThis is the first report on the immunological characterization of cystatin proteins and gene sequencing in H. doenitzi. Cystatin proteins are promising antigens that have the potential for use as vaccines for H. doenitzi infestation control.This article is protected by copyright. All rights reserved.

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“…Natural repellents and chemical acaricides are the most common tick control interventions, and recent advances in plant-derived natural compounds and anti-tick vaccines provide new environmentally sound, effective, and sustainable control interventions (Malak et al 2024 ; de la Fuente and Ghosh 2024 ). Nevertheless, rational integration of different control interventions including management of natural predators is required for innovative approaches to reduce the risks associated with ticks and tick-borne diseases (de la Fuente et al 2023 ; Machtinger et al 2024 ).…”

Section: Introductionmentioning

confidence: 99%

Interaction between spiders and ticks—ancient arthropod predatory behavior?

de la Fuente,

Estrada-Peña,

Labruna

et al. 2024

Parasitol Res

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Ticks are ectoparasite vectors of pathogens affecting human and animal health worldwide. Rational integration of different control interventions including plant-derived repellents and acaricides, management of natural predators, and vaccines is required for innovative approaches to reduce the risks associated with ticks and tick-borne diseases. How tick populations are naturally controlled is always a question. Tick interactions with other arthropods including predators evolved from ancient times. In this study, Cretaceous (ca. 100 Mya) Burmese amber inclusions were identified as probably related to Compluriscutula vetulum (Acari: Ixodida: Ixodidae) tick larvae and spider silk. As illustrated in this study, ancient interactions between ticks and spiders may support arthropod predatory behavior as a natural control intervention. Rational integrative management of different tick control interventions including natural predators under a One Health perspective will contribute to effectively and sustainably reducing the risks associated with ticks and tick-borne diseases.

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Innovative approaches for the control of ticks and tick-borne diseases

Cited by 9 publications

References 59 publications

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

The evaluation of cystatin protein vaccines based on the stress response of ticks triggered by low‐temperature and toxin stress in Haemaphysalis doenitzi

Interaction between spiders and ticks—ancient arthropod predatory behavior?

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