Innovative Approaches for Breast Cancer Metastasis to the Brain

Abstract

Breast cancer metastasis is a continued concern for patients with recent development in our understanding of disease progression. In this paper, we highlight the pathophysiology behind breast cancer metastasis. Blood brain barrier disruption plays a critical component in progression. We then investigate the current treatment strategies and recommended guidelines. This focuses on radiation and medical management. Finally, we address the role of surgical intervention. The data is organized into tables and figures to highlight key components. Finally, we address emerging treatments and pre-clinical data. The paper will serve as a user-friendly guide for clinicians and researchers to help formulate a strategy to manage breast cancer metastasis patients sufficiently.

Research trends and prospects on brain metastasis from breast cancer: A bibliometric analysis

“…These therapies include surgical resection, stereotactic radiotherapy, and whole brain radiotherapy. The approach chosen for treatment is individualized based on the extent and characteristics of the brain metastasis ( 37 , 38 ). For patients with endocrine-resistant breast cancer who develop brain metastasis and are resistant to most chemotherapies, surgical tumor resection and stereotactic radiotherapy have demonstrated efficacy in improving overall survival and reducing symptoms associated with brain metastasis, which remains crucial in optimizing outcomes for this population ( 39 ).…”

Efficacy and Safety of Radiotherapy Combined with Pyrotinib in the Treatment of HER2-Positive Breast Cancer with Brain Metastases

“…47 Some studies have identified several potential biomarkers associated with BCBM, and their quantitative analysis may be a reliable indicator for evaluating the rationality of MRI imaging in BC patients with asymptomatic BM. 48 Brain MRI screening is only recommended when a patient has symptoms of suspected intracranial metastases, and the chances of early treatment of BM will be greater if closer brain monitoring can be performed when the patient has high-risk factors like visceral metastases. 27 Showing no difference with earlier issued data, 31,36 The security analysis of this research showed that the most usual untoward reaction was diarrhea.…”