Innovative Adjunctive Approaches to Wound Management

Theoret, Christine L.; Lepage, Olivier; Dart, Andrew; Bischofberger, Andrea S; Stanley, Brian; Koenig, Judith B.

doi:10.1002/9781118999219.ch22

Cited by 5 publications

(6 citation statements)

References 151 publications

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“…The use of an artificial dermis scaffold and soft tissue expansion to repair the defect highlights the need for a dynamic and multimodal approach to successfully manage such cases. Tissue engineering is an exciting area of science in which rapid developments are being made (Theoret 2017), and future research in this area will be important to further advancements in equine wound management. However, a wide number of products are available with major inconsistencies in their production and action (Theoret 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Tissue engineering is an exciting area of science in which rapid developments are being made (Theoret 2017), and future research in this area will be important to further advancements in equine wound management. However, a wide number of products are available with major inconsistencies in their production and action (Theoret 2017). Clinical trials of their use in equine wounds are indicated before specific products or therapeutic approaches can be recommended.…”

Section: Discussionmentioning

confidence: 99%

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Surgical repair of a full‐thickness ear pinna defect in a horse

Cullen

Ehrle

Willson

et al. 2021

Equine Veterinary Education

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A 5-year-old gelding used for showing was presented for surgical repair of a full-thickness 15 mm diameter defect in the right pinna, which had occurred as a delayed complication following laser excision of a sarcoid. The defect had resulted in progressive deformity of the ear, and the horse was considered at risk of further injury if the defect became entrapped on a fixed object. Two artificial dermis meshes were inserted to encourage the formation of granulation tissue across the defect, and a commercially available skin expander was implanted adjacent to the site. Eighteen days later, a second surgery was performed to remove the skin expander and to mobilise a local rotational skin flap to close the defect. Both surgeries were performed under standing sedation and local anaesthesia. The site healed well, avoiding further potential trauma to the ear and deformity due to tissue contracture at the site, although some deformation of the lateral aspect of the cartilage remained.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surgical repair of a full‐thickness ear pinna defect in a horse

Cullen

Ehrle

Willson

et al. 2021

Equine Veterinary Education

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“…Several studies have been carried out to develop novel therapeutic alternatives for both horses and humans with non-healing skin wounds [3,[9][10][11]. Most of these studies focused on the promising clinical therapeutic using of stem cells for treatment of non-healing and recurrent immune-mediated skin diseases which have not responded to the conventional therapy [6,12,13].…”

Section: Introductionmentioning

confidence: 99%

Clinical Effect of Mesenchymal Stem cell-Derived Microvesicles as Adjunctive Treatment to Surgery on Healing of Distal Limb Chronic Wounds in Arabian Horses

Hassan,

Abdallah,

Shamaa

et al. 2024

Egyptian Journal of Veterinary Sciences

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ISTAL limb wounds in horses account for more than 60% of all wounds. This study described the clinical effect of mesenchymal stem cell-derived microvesicles (MVs) on healing of equine distal limb chronic wounds. Twelve Arabian horses with distal limb granulating wounds (Group I, n=6) or ulcerated wounds (Group II, n=6) were treated surgically either by excision of the granulating masses or debridement of ulcers. In group I, the horses were divided randomly into two subgroups (3 horses each); subgroup 1 was given two doses of topical and subcutaneous injection of MVs after surgery. Subgroup 2 (control) was treated only by surgery. Group II was divided randomly into two equal subgroups; subgroup 1 was given one dose of topical and subcutaneous injection of MVs after surgery and subgroup 2 was treated by debridement (control). Healing progression was documented using digimizer image analysis software and data were statistically analyzed. The mean areas of the granulating and ulcerating wounds were 81.71±3.25 cm2 and 18.91±1.78 cm2, respectively. In group I, complete wound healing was achieved on days 70±3.5 and 100±4.32 in subgroups 1 and 2, respectively. However, complete wound healing was achieved in group II on days 27±2.3 and 41±3.1 in subgroups 1 and 2, respectively. There were statistically significant differences in wound area reduction between the two subgroups in both groups (P< .05). In conclusion, this preliminary study indicated that topical and subcutaneous injection of MVs after surgical interferences may enhance healing of the chronic wounds in distal limbs of horses.

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“…Os desafios relacionados às áreas afetadas incluem a incapacidade de imobilizar e/ou confinar pacientes, assim como, manter a assepsia da lesão durante os estágios iniciais que são considerados críticos para a evolução da cicatrização (DALHGREN, 2018). Nas lacerações agudas que envolvem tecidos moles em região de talão, o emprego de sutura, bem como sua manutenção, não é considerado eficiente devido à localização, mobilidade e principalmente a tensão exercida pela pele na área acometida (THEORET et al, 2016).…”

Section: Introductionunclassified

Utilização de três técnicas de ozonioterapia no tratamento de ferida em região de casco e talão equino - Relato de caso / Use of three ozonetherapy techniques in the treatment of wounds in the equine hull and heel region - Case report

Flamia¹,

Wilmsen²

2021

BJDV

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A ocorrência de lesões perfurocortantes consistem em uma rotina comum na clínica de equinos. Nos traumas que resultam em feridas abertas, a abordagem terapêutica resulta em tratamentos longos e por segunda intenção até a recuperação e reestabelecimento total da área e tecido afetado. A cicatrização representa um processo dinâmico que inicia imediatamente após o trauma e é composta por quatro fases, sendo elas: inflamação, desbridamento, reparação e maturação do local afetado. Um dos desafios na cicatrização de ferida na espécie equina é a formação de tecido de granulação exuberante, que pode implicar no aumento do período de tratamento, infecções recorrentes, redução da contração da ferida em função do acometimento em locais de maior movimentação e ainda a intensidade do trauma. A fim de tentar minimizar o tempo de tratamento das feridas com cicatrização por segunda intenção, a utilização de técnicas de terapias alternativas como a ozonioterapia, auxiliam nas etapas de desbridamento, desinfecção e reparação da área afetada. Assim, este caso relato o atendimento de um equino da raça Quarto de milha com 18 anos, macho, castrado, aproximadamente 600 kg, com uma lesão em membro pélvico esquerdo em região de casco, cório perióplico, talão e ranilha, com evolução de 8 horas após o trauma. Para o controle da inflamação foi utilizado meloxicam 2% (10mg/kg) por via intramuscular (SID) durante quatro dias. A fim de potencializar o efeito de cicatrização foram utlizadas três técnicas de ozonioterapia ao longo de todo tratamento que durou 90 dias até a cicatrização total da lesão. Portanto, o objetivo desse trabalho é relatar o uso da ozonioterapia em uma ferida em região de casco envolvendo o cório perióplico, talão e ranilha utilizando óleo ozonizado, ozônio em Bagging e auto hemoterapia ozonizada em um equino da raça Quarto de Milha.

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Innovative Adjunctive Approaches to Wound Management

Cited by 5 publications

References 151 publications

Surgical repair of a full‐thickness ear pinna defect in a horse

Surgical repair of a full‐thickness ear pinna defect in a horse

Clinical Effect of Mesenchymal Stem cell-Derived Microvesicles as Adjunctive Treatment to Surgery on Healing of Distal Limb Chronic Wounds in Arabian Horses

Utilização de três técnicas de ozonioterapia no tratamento de ferida em região de casco e talão equino - Relato de caso / Use of three ozonetherapy techniques in the treatment of wounds in the equine hull and heel region - Case report

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