Innovations in Keratoprosthesis: Proved and Unproved

Yaghouti, Farzad; Dohlman, Claes H.

doi:10.1097/00004397-199903910-00005

Cited by 27 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glaucoma is a frequent and severe complication after the keratoprothesis, particularly in cicatrizing conditions, such as chemical burn, etc 12. None of our 4 eyes developed glaucoma after the implantation of KPro.…”

Section: Discussionmentioning

confidence: 62%

“…The difference between the best and the worst group differed markedly and has been documented to correlate well with the degree of the preoperative inflammation. According to the degree of the vision achieved and retention rate, Yaghouti and Dohlman12 classified the prognosis ranking (best to worst) as follows: 1) Graft failure in the eyes without past inflammation (corneal edema, etc. ); 2)Graft failure in eyes with past inflammation (past herpes simplex or zoster, uveitis, etc.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Short-term visual outcomes of Boston keratoprosthesis type I in Saudi Arabia

Arfaj

Hantera

2012

Middle East Afr J Ophthalmol

View full text Add to dashboard Cite

Purpose:To evaluate the visual outcomes, complications and retention of threadless type I Boston keratoprosthesis (KPro) in Saudi Arabia.Materials and Methods:Retrospective analysis of four eyes of four patients (one female and three males; age range: 48 to 72 years) who underwent Boston type I threadless KPro implantation between January and December 2009.Results:In the median follow-up of 11 months (range 6 to 14 months), visual outcomes were satisfactory. Preoperative diagnosis included two patients of post-trachoma dense vascularized corneal scarring, one patient of corneal alkali burn and one patient of repeated failed corneal grafts. All patients demonstrated significant improvement in vision; with pre-operative visual acuity of hand movements (HM), counting fingers and HM improved to best corrected visual acuity (BCVA) of 20/200, 20/60, 20/50 and 20/30 on their last follow-up visits respectively. None of the patients developed glaucoma as a result of the procedure. No retro-prosthetic membrane developed till the last follow-up visit. One of the four patients had a corneal melt (due to severe dryness associated with trachoma) 6 months after the KPro implantation and underwent a successful KPro revision. Despite the relatively poor prognosis expected in alkali burn eye, the patient attained the maximum BCVA (20/30) of the four eye series on the last follow-up visit at six months.Conclusion:In consistent with the earlier reports from other parts of the world, all the 4 eyes had a significant increase in vision after Boston type I KPro implantation. However, patients require close lifelong follow-up to manage any complications.

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Short-term visual outcomes of Boston keratoprosthesis type I in Saudi Arabia

Arfaj

Hantera

2012

Middle East Afr J Ophthalmol

View full text Add to dashboard Cite

show abstract

“…This device, which is implanted as a full-thickness replacement along with a rim of donor graft tissue, is successful in restoring visual acuity and can persist in a patient's eye for years (23). However, it is prone to a number of complications, including retroprosthetic membrane formation, glaucoma, extrusion, endophthalmitis, and rejection (24)(25)(26). Nevertheless, it has been implanted successfully in hundreds of patients worldwide and has recently been shown to work particularly well when used in conjunction with a soft contact lens (27).…”

Section: Pioneering Plastics In Corneal Prosthesesmentioning

confidence: 99%

Development of Hydrogel‐Based Keratoprostheses: A Materials Perspective

Myung

Duhamel

Cochran

et al. 2008

Biotechnology Progress

103

View full text Add to dashboard Cite

Research and development of artificial corneas (keratoprostheses) in recent years have evolved from the use of rigid hydrophobic materials such as plastics and rubbers to hydrophilic, waterswollen hydrogels engineered to support not only peripheral tissue integration but also glucose diffusion and surface epithelialization. The advent of the AlphaCor core-and-skirt hydrogel keratoprosthesis has paved the way for a host of new approaches based on hydrogels and other soft materials that encompass a variety of materials preparation strategies, from synthetic homopolymers and copolymers to collagen-based bio-copolymers and, finally, interpenetrating polymer networks. Each approach represents a unique strategy toward the same goal: to develop a new hydrogel that mimics the important properties of natural donor corneas. We provide a critical review of these approaches from a materials perspective and discuss recent experimental results. While formidable technical hurdles still need to be overcome, the rapid progress that has been made by investigators with these approaches is indicative that a synthetic donor cornea capable of surface epithelialization is now closer to becoming a clinical reality.

show abstract

“…Many of the complications that lead to the ultimate extrusion of these devices may be due to the lack of surface epithelialization over the synthetic material. These complications include intraocular infections (endophthalmitis), extrusion, epithelial downgrowth, and glaucoma, each of which can be devastating and lead to severe, irreversible loss of vision [1][2][3] . The lack of epithelial coverage over a keratoprosthesis may allow for bacteria or epithelial cells to gain access to the eye, particularly at the interface between the artifi cial cornea and host tissue.…”

Section: Introductionmentioning

confidence: 99%

Glucose Permeability of Human, Bovine, and Porcine Corneas in vitro

et al. 2006

View full text Add to dashboard Cite

Purpose: To measure glucose flux across human, bovine, and porcine corneas and to determine the diffusion coefficient of each type of cornea. Methods: Diffusion of glucose across human (n = 8), bovine (n = 7), and pig corneas (n = 8) was measured using a modified blind well chamber apparatus (Boyden chamber). Dialysis membranes (n = 7) and nonporous Mylar membranes (n = 7) were used as positive and negative controls, respectively. Glucose concentrations were measured at 30-min intervals with a commercially available glucose meter. Results: The diffusion of glucose through corneas in vitro was calculated by a simple Fickian diffusion model. The diffusion coefficient of glucose is highest for the human cornea (D_HC = 3.0 ± 0.2 × 10^–6 cm²/s) followed by porcine corneas (D_PC = 1.8 ± 0.6 × 10^–6 cm²/s) and bovine corneas (D_BC = 1.6 ± 0.1 × 10^–6 cm²/s) (p < 0.05). The diffusion coefficients of all tested corneas were significantly higher (p < 0.05) than that of dialysis membrane (D_DM = 3.4 ± 0.2 × 10^–7 cm²/s). Conclusion: The glucose diffusion coefficients of human, bovine, and porcine corneas are on the order of 10^–6. Human corneas have higher permeability to glucose than either porcine or bovine corneas.

show abstract

Innovations in Keratoprosthesis: Proved and Unproved

Cited by 27 publications

References 0 publications

Short-term visual outcomes of Boston keratoprosthesis type I in Saudi Arabia

Short-term visual outcomes of Boston keratoprosthesis type I in Saudi Arabia

Development of Hydrogel‐Based Keratoprostheses: A Materials Perspective

Glucose Permeability of Human, Bovine, and Porcine Corneas in vitro

Contact Info

Product

Resources

About