One of the primary reasons for discernible or complete loss of sight in middle-aged and older persons is central retinal vein occlusion (CRVO). Three intravitreal bevacizumab (Avastin) injections were administered to a 39-year-old male patient as part of his therapy for his prior diabetic retinopathy due to uncontrolled diabetes. The patient was advised to undergo gonioscopy and an undilated iris examination to look for angle neovascularization during the next three months of follow-up. We demonstrated an extraordinary instance of unilateral ischemia CRVO (macular edema), where the main cause of risk was insulin resistance. To avoid a situation like this, close observation and diabetes management are recommended.