Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation
Beatrice Xuan Ho,
Adrian Kee Keong Teo,
Natasha Hui Jin Ng
Abstract:Human allogeneic pancreatic islet transplantation is a life-changing treatment for patients with severe Type 1 Diabetes (T1D) who suffer from hypoglycemia unawareness and high risk of severe hypoglycemia. However, intensive immunosuppression is required to prevent immune rejection of the graft, that may in turn lead to undesirable side effects such as toxicity to the islet cells, kidney toxicity, occurrence of opportunistic infections, and malignancies. The shortage of cadaveric human islet donors further limi… Show more
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