Innovation Management? Orienting Sepsis R&amp;D and Technology Transfer Towards Stratified Medicine

Özdemir, Vural; Hekim, Nezih

doi:10.1016/j.ebiom.2016.04.007

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…An inflammatory response to an infection is known as sepsis. When sepsis is associated with dysfunction of any of the organ system or failure of the circulation, it is known as severe sepsis or septic shock, respectively [6,7]. The increased life expectancy of individuals (including those who are immune-compromised) and the surge seen with the utilization of invasive medical interventions are all important contributors to the high incidence of sepsis and its complications.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Outcome Among Severe Sepsis and Septic Shock Patients in a South Indian Tertiary Care Hospital

Babu

Menon

Devi

2017

Int J Pharm Pharm Sci

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Objective: The objective of this research was to determine the prevalence of severe sepsis and septic shock and evaluate its outcome.Methods: This was a prospective, observational study, in which adult patients with severe sepsis or septic shock were included. Relevant information was collected from medical records and the hospital information system. Results:A total of 250 patients [mean age 57.2 y (range: 18 to 98 y)] was studied. The majority of the patients suffered from severe sepsis (81.2%). Most of the episodes occurred in males (75.2%). Major comorbidities included diabetes mellitus (51.2%), hypertension (44.8%) and chronic liver disease (30.4%). One hundred and seventy-eight patients (147 patients with severe sepsis and 31 patients with septic shock) had a positive culture with urine being the main site of infection. One hundred and two patients (40.8%) had a monomicrobial infection while seventy-six (30.4%) patients had a polymicrobial infection. Within the monomicrobial infections, the gram negative organisms predominated (54%). The mean hospital stay for patients with severe sepsis was 11.5 d. Mortality was noted in 79 patients (40 patients with septic shock and 39 patients with severe sepsis). Conclusion:The main causative pathogens were gram negative bacteria. Admissions meeting septic shock criteria have a high mortality rate. Hence, it is imperative to identify patients who are at high risk and treat them promptly to reduce serious consequences.

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Section: Introductionmentioning

confidence: 99%

Epidemiology and Outcome Among Severe Sepsis and Septic Shock Patients in a South Indian Tertiary Care Hospital

Babu

Menon

Devi

2017

Int J Pharm Pharm Sci

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“…This is especially relevant in low-resource environments, such as the developing countries, where the absence of license fees and adaptability to local needs have proven the utility of FLOSS as a sustainable technology and knowledge transfer tool, and effectively lower entry barriers for omics research (Alkhatib et al, 2008). Especially in the case of sepsis, FLOSS may be proven an indispensable element of Research and Development (R&D) reshaping as well as technology transfer reorientation, next to other open innovation initiatives, such as innovative funding designs (e.g., crowdsourcing) and new R&D modes (O ¨zdemir and Hekim, 2016).…”

Section: Key Findingsmentioning

confidence: 99%

Use of Free/Libre Open Source Software in Sepsis “-Omics” Research: A Bibliometric, Comparative Analysis Among the United States, EU-28 Member States, and China

Evangelatos

Satyamourthy

Levidou

et al. 2018

OMICS: A Journal of Integrative Biology

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"-Omics" systems sciences are at the epicenter of personalized medicine and public health, and drivers of knowledge-based biotechnology innovation. Bioinformatics, a core component of omics research, is one of the disciplines that first employed Free/Libre Open Source Software (FLOSS), and thus provided a fertile ground for its further development. Understanding the use and characteristics of FLOSS deployed in the omics field is valuable for future innovation strategies, policy and funding priorities. We conducted a bibliometric, longitudinal study of the use of FLOSS in sepsis omics research from 2011 to 2015 in the United States, EU-28 and China. Because sepsis is an interdisciplinary field at the intersection of multiple omics technologies and medical specialties, it was chosen as a model innovation ecosystem for this empirical analysis, which used publicly available data. Despite development of and competition from proprietary commercial software, scholars in omics continue to employ FLOSS routinely, and independent of the type of omics technology they work with. The number of articles using FLOSS increased significantly over time in the EU-28, as opposed to the United States and China (R = 0.96, p = 0.004). Furthermore, in an era where sharing of knowledge is being strongly advocated and promoted by public agencies and social institutions, we discuss possible correlations between the use of FLOSS and various funding sources in omics research. These observations and analyses provide new insights into the use of FLOSS in sepsis omics research across three (supra)national regions. Further benchmarking studies are warranted for FLOSS trends in other omics fields and geographical settings. These could, in time, lead to the development of new composite innovation and technology use metrics in omics systems sciences and bioinformatics communities.

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“…The environment can play a decisive role in the extent to which individuals are differentially susceptible to disease as well as to the toxicity associated with therapeutic interventions. Environmental factors include technology and innovation policy but do not always receive the same degree of enthusiastic interest from the scientific community, compared with, for example, host-related variables such as genomic and proteomic variation among people and populations (Dandara et al, 2014 ; Ozdemir and Hekim, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenomics and Global Precision Medicine in the Context of Adverse Drug Reactions: Top 10 Opportunities and Challenges for the Next Decade

Alessandrini

Chaudhry

Dodgen

et al. 2016

OMICS: A Journal of Integrative Biology

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In a move indicative of the enthusiastic support of precision medicine, the U.S. President Barack Obama announced the Precision Medicine Initiative in January 2015. The global precision medicine ecosystem is, thus, receiving generous support from the United States ($215 million), and numerous other governments have followed suit. In the context of precision medicine, drug treatment and prediction of its outcomes have been important for nearly six decades in the field of pharmacogenomics. The field offers an elegant solution for minimizing the effects and occurrence of adverse drug reactions (ADRs). The Clinical Pharmacogenetics Implementation Consortium (CPIC) plays an important role in this context, and it aims at specifically guiding the translation of clinically relevant and evidence-based pharmacogenomics research. In this forward-looking analysis, we make particular reference to several of the CPIC guidelines and their role in guiding the treatment of highly relevant diseases, namely cardiovascular disease, major depressive disorder, cancer, and human immunodeficiency virus, with a view to predicting and managing ADRs. In addition, we provide a list of the top 10 crosscutting opportunities and challenges facing the fields of precision medicine and pharmacogenomics, which have broad applicability independent of the drug class involved. Many of these opportunities and challenges pertain to infrastructure, study design, policy, and science culture in the early 21st century. Ultimately, rational pharmacogenomics study design and the acquisition of comprehensive phenotypic data that proportionately match the genomics data should be an imperative as we move forward toward global precision medicine.

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Innovation Management? Orienting Sepsis R&D and Technology Transfer Towards Stratified Medicine

Cited by 6 publications

References 10 publications

Epidemiology and Outcome Among Severe Sepsis and Septic Shock Patients in a South Indian Tertiary Care Hospital

Epidemiology and Outcome Among Severe Sepsis and Septic Shock Patients in a South Indian Tertiary Care Hospital

Use of Free/Libre Open Source Software in Sepsis “-Omics” Research: A Bibliometric, Comparative Analysis Among the United States, EU-28 Member States, and China

Pharmacogenomics and Global Precision Medicine in the Context of Adverse Drug Reactions: Top 10 Opportunities and Challenges for the Next Decade

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