Innovation in the Transport of Cytotoxic Drugs by a Pneumatic Transport System

Baillie, Constance; Desplanques, Marion; Delbey, Stéphanie; Sakji, Ilyes; Feutry, Frédéric

doi:10.1515/pthp-2016-0022

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…For example, some hospitals use CSTD for the reconstitution of all drugs, proteins or not, even in the absence of compatibility information [ 23 , 24 ]. Similarly, the PTS has been recently installed in different hospitals in Europe, even for chemotherapy transport [ 25 ]; however, the formation of subvisible particles and the possible adverse impact on the product quality is still a concern of consideration [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

How are we handling protein drugs in hospitals? A human factors and systems engineering approach to compare two hospitals and suggest a best practice

Sabaté-Martínez,

Paulsson,

González-Suárez

et al. 2024

International Journal for Quality in Health Care

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Background Biopharmaceuticals are complex biological molecules that require careful storage and handling to ensure medication integrity. In this study, a work system analysis of real-world protein drug (PD) handling was performed with the following goals: identify main barriers and facilitators for successful adherence to accepted recommendations in PD handling, analyse differences in two organisations, and define a Best Current Practice in the real-life handling of PDs based on the results of the work system analysis. Methods Observational study held in two university hospitals in Spain and Sweden. Based on the Systems Engineering Initiative for Patient Safety (SEIPS) model, the tools chosen were: the PETT scan, in order to indicate the presence of barriers or facilitators for the PETT components (People, Environment, Tools, Tasks); the Tasks and tools matrices to construct a checklist to record direct observations during the real-life handling of biopharmaceuticals, and the Journey map to depict the work process.Observations were performed between March-November 2022. Each episode of direct observation included a single protein drug in some point of the supply chain and considered all the elements in the work system. Based on the results of the work system analysis and the literature review, the authors propose a list of items which could be assumed as Best Current Practice for PDs handling in hospitals. Results There were a total of 34 observations involving 19 PDs. Regarding People involved in the work process, there was a diversity of professionals with different previous training and knowledge, leading to an information gap. With respect to Environment, some structural and organizational differences between hospitals lead to risks related to the time exposure of PDs to room temperature and mechanical stress. Some differences also existed in the Tools and Tasks involved in the process, being especially relevant the lack of compatibility information of PDs with new technologies, such as pneumatic tube system, robotic reconstitution or closed-system transfer devices. Finally, 15 suggestions for best current practice are proposed. Conclusion Main barriers found for compliance with accepted recommendations were related to the information gap detected in professionals involved in the handling of protein drugs, unmonitored temperature and the lack of compatibility information of protein drugs with some new technologies. By applying a Human Factors and Systems Engineering Approach, the comparison of two European hospitals has led to a suggested list of Best Current Practices in the handling of protein drugs in a hospital.

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