Sustainability, as well as a concept related to a development model, is becoming a real guide to drive the governance choices of value chains. A sustainable policy has the objective of perpetuating production models over time while maintaining the environmental, economic and social dimensions that characterize a given production process. It is therefore important to measure the sustainability of a production system in its environmental, social and economic components and to understand the ongoing trends under the pressure of agricultural policies, market dynamics and innovation pattern introduced along the time in a production system. The purpose of the article is to assess the evolution of the level of sustainability of Parmigiano Reggiano production system under the effect of 20 years of innovation mechanism which impact on product quality, value chain performance and rural development. To this aim the paper discuss a holistic framework that allows the representation of stakeholder’s role considering the value chain and the territorial dimension. The paper discus also the use of dimensional indicators and propose a use of synthetic indexes to provide an overall picture of the evolution of sustainability of specific production system.