Innflutt fersk matvæli og sýkingaráhætta fyrir menn

Kristinsson, Karl G.; Georgsson, Franklín

doi:10.17992/lbl.2015.06.32

Cited by 2 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several proteinases, including neutrophil elastase, cathepsin G and chymotrypsin can have inhibitory effects at PAR1 and PAR2 such that they cleave the exodomain of the receptor without inducing activation of Gαq-coupled calcium signalling, thereby preventing activation by activating proteinases but not by agonist peptides. Neutrophil elastase (NE) cleavage of PAR1 and PAR2 can however activate MAP kinase signaling by exposing a TL that is different from the one revealed by trypsin [1764] Endogenous agonists QRFP26 (QRFP) [343,999] Agonists LV-2186 [41], LV-2172 [1572] Selective antagonists compound 25e (pIC 50 7.3) [687,688] Labelled ligands [ 125 I]QRFP43 (human) (Agonist) [641,1164,2090], [ 125 I]26RFa (human) (Agonist) [260] Comments: The orphan receptor GPR83 (9NYM4) shows sequence similarities with the QRFP receptor, as well as with the NPFF1, NPFF2, and PrRP receptors. ).…”

Section: Proteinase-activated Receptorsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Alexander

Christopoulos

Davenport

et al. 2019

British J Pharmacology

625

621

View full text Add to dashboard Cite

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (http://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14748. G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

show abstract

Section: Proteinase-activated Receptorsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Alexander

Christopoulos

Davenport

et al. 2019

British J Pharmacology

625

621

View full text Add to dashboard Cite

show abstract

Salmonella enterica Transmission and Antimicrobial Resistance Dynamics across One-Health Sector

Uzairue¹,

Shittu²

2024

Salmonella - Perspectives for Low-Cost Prevention, Control and Treatment

View full text Add to dashboard Cite

From human infection to animal production and the environment, Salmonella enterica has become a global-threat. The pathogen’s dynamics have been determined by its transfer from sector to sector. Antibiotic-resistant bacteria can survive and proliferate in antibiotics. Misuse of antibiotics has made certain S. enterica resistant. The One-Health sector has antibiotic-resistant Salmonella (an approach that recognizes that human health is closely connected to the health of animals and the shared environment). According to certain studies, most animal and environmental S. enterica have virulence genes needed for human infections. S. enterica antibiotic resistance patterns have varied over the decades, resulting in pan-drug-resistant-strains. Plasmid-mediated fluoroquinolone resistance genes are found in One-Health Salmonella species. The S. enterica subspecies Typhi has been found to be extensively drug-resistant (XDR) in some areas. Cephalosporin-resistant S. enterica subspecies Typhi is a severe problem that underscores the need for Vi-conjugat-vaccines. New diagnostics for resistant-Salmonella in food, animal, environment, and human sectors are needed to control the spread of these deadly infections. Also, hygiene is essential as reduced transmissions have been recorded in developed countries due to improved hygienic practices. This chapter aims to discuss the transmission and antimicrobial resistance dynamics of S. enterica across the One-Health sector.

show abstract

Innflutt fersk matvæli og sýkingaráhætta fyrir menn

Cited by 2 publications

References 34 publications

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Salmonella enterica Transmission and Antimicrobial Resistance Dynamics across One-Health Sector

Contact Info

Product

Resources

About