Innervation of the Spinal Dura

Kumar, Rakesh; Berger, Richard J.; Dunsker, Stewart B.; Keller, Jeffrey T.

doi:10.1097/00007632-199601010-00004

Cited by 58 publications

(28 citation statements)

References 26 publications

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“…Kumar et al [39] reported a sparse innervation of CGRP-and SP-positive neurons in the ventral part of the dura mater lumbalis, but observed no fibers in the dorsal dura. In contrast to this finding, other authors demonstrated a network of CGRPand SP-positive primary afferents in the ventral dura mater lumbalis and a less dense innervation in the dorsal aspects [1,2,30,39]. The present study confirms the sensory peptidergic innervation of the ventral as well as the dorsal parts of the lumbar dura and adds quantitative data on their innervation density.…”

Section: Innervation Of the Spinal Dura Mater Lumbalissupporting

confidence: 54%

The density of nociceptive SP- and CGRP-immunopositive nerve fibers in the dura mater lumbalis of rats is enhanced after laminectomy, even after application of autologous fat grafts

Saxler¹,

Brankamp²,

Knoch³

et al. 2008

Eur Spine J

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A considerable number of patients complain about pain after lumbar surgery. The spinal dura mater has been debated as a possible source of this pain. However, there is no information if laminectomy influences the nociceptive sensory innervation of the dura. Therefore, we quantitatively evaluated the density of SP-and CGRPimmunopositive nerve fibers in the dura mater lumbalis in an animal model of laminectomy. Twelve adult Lewis rats underwent laminectomy, in six of them the exposed dura was covered by an autologous fat graft. Further six animals without surgical treatment served as controls. Six weeks after surgery, the animals were perfused and the lumbar dura was processed immunohistochemically for the detection of CGRP-and SP-containing nerve fibers. In controls, the peptidergic nerve fibers were found predominantly in the ventral but rarely in the dorsal dura mater lumbalis. After laminectomy, the density of SP-and CGRP-immunopositive neurons significantly increased in ventral as well as in dorsal parts of the dura. Axonal spines could be observed in some cases at the site of laminectomy. The application of autologous fat grafts failed to inhibit the significant increase in the density of peptidergic afferents. Thus, we have provided the first evidence that laminectomies induce an increase in the density of putative nociceptive SP-and CGRP-immunopositive neurons in the lumbar dura mater ascribable to an axonal sprouting of fine nerve fibers. This effect was not prevented by using autologous fat grafts. It is conceivable that the neuronal outgrowth of nociceptive afferents is a cause of low back pain observed after lumbar surgery.

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Section: Innervation Of the Spinal Dura Mater Lumbalissupporting

confidence: 54%

The density of nociceptive SP- and CGRP-immunopositive nerve fibers in the dura mater lumbalis of rats is enhanced after laminectomy, even after application of autologous fat grafts

Saxler¹,

Brankamp²,

Knoch³

et al. 2008

Eur Spine J

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“…Some recent studies (Groen et al, 1988;Kallakuri et al, 1998;Kumar et al, 1996;Yamada et al, 1998) have provided new light on this topic but, in any case, did not furnish an unequivocal interpretation of the different pattern of innervation. Our experimental observations are confined to human and rodents' dura mater and led us to describe some interesting findings in the examined species.…”

Section: Introductionmentioning

confidence: 96%

Catecholaminergic and acetylcholine esterase containing nerves of cranial and spinal dura mater in humans and rodents

Artico

Cavallotti

2001

Microscopy Res & Technique

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The innervation of cranial and spinal dura mater in humans and rodents was studied by examining several dural zones (vascular, perivascular, intervascular) in different regions. Characterization and distribution of dural acetylcholinesterase-positive nerve fibers, catecholaminergic nerve fibers, and mast cells are analyzed and discussed. The results of chemical and surgical sympathectomy as well as the relationships between catecholaminergic nerve fibers and mast cells are studied. Our results are discussed in the light of possible implications in the physiopathology of dural algic syndromes including cephalalgia and spinal pain.

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“…The ventral dural nerves may extend up to eight segments, with a great amount of overlap between adjacent nerves. Somatosensory (CGRP-and SP-positive) fibers along dural root sleeves in the cervical and lumbar regions have also been demonstrated (Kumar et al, 1996). The majority of these fibers are autonomic (Groen et al, 1988).…”

Section: Innervation Of the Meningesmentioning

confidence: 55%

The Vertebral Column and Spinal Meninges

Kayalıoğlu¹

2009

The Spinal Cord

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Innervation of the Spinal Dura

Cited by 58 publications

References 26 publications

The density of nociceptive SP- and CGRP-immunopositive nerve fibers in the dura mater lumbalis of rats is enhanced after laminectomy, even after application of autologous fat grafts

The density of nociceptive SP- and CGRP-immunopositive nerve fibers in the dura mater lumbalis of rats is enhanced after laminectomy, even after application of autologous fat grafts

Catecholaminergic and acetylcholine esterase containing nerves of cranial and spinal dura mater in humans and rodents

The Vertebral Column and Spinal Meninges

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